Stains
Claudins - general


Topic Completed: 1 July 2013

Minor changes: 16 October 2020

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PubMed Search: claudins

Nat Pernick, M.D.
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Cite this page: Pernick N. Claudins - general. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsclaudins.html. Accessed December 4th, 2020.
Definition / general
  • Multigene family of integral membrane proteins active in tight junction formation and function
  • Claudins were first named in 1998 by Japanese researchers Mikio Furuse and Shoichiro Tsukita at Kyoto University, based on the Latin claudere ("to close"), suggesting the barrier role of these proteins ( J Cell Biol 1998 Jun 29;141:1539)
  • Most claudin genes appear decreased in cancer, while CLDN3, CLDN4 and CLDN7 are elevated in several malignancies (BMC Cancer 2006;6:186)
Pathophysiology
  • Tight junctions (zonula occludens) form continuous barrier to fluids across epithelium and endothelium; regulate paracellular permeability and maintain cell polarity by blocking movement of transmembrane proteins between apical and basolateral cell surfaces (Annu Rev Cell Dev Biol 2006;22:207)
  • Tight junctions are composed of claudin and occludin proteins, which join the junctions to the cytoskeleton
  • Claudin family has > 20 integral membrane proteins, expressed in tissue specific pattern that may determine strength and properties of epithelial barrier; usually cells from a specific organ express multiple claudin proteins
Positive staining - normal
  • Epithelial and endothelial cells
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