Topic Completed: 1 October 2013

Revised: 4 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: Clusterin[title] stain

Nat Pernick, M.D.
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Cite this page: Pernick N. Clusterin. website. Accessed November 15th, 2019.
Definition / general
  • Glycoprotein implicated in apoptosis and other cellular functions
  • Strongly expressed in follicular dendritic cell tumors, weak/no expression in other dendritic cell tumors
  • Among spindle cell neoplasms, has high sensitivity and specificity for follicular dendritic cell tumors (Mod Pathol 2005;18:260)
Positive staining - disease
  • Anaplastic large cell lymphoma (80-100% of systemic cases, 40-60% of primary cutaneous cases), diffuse large B cell lymphoma (12%), carcinomas of breast, colon, pancreas, prostate
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