Author: Nat Pernick, M.D.

Revised: 10 May 2018, last major update October 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Clusterin[title] stain
Cite this page: Pernick, N. Clusterin. website. Accessed July 17th, 2018.
Definition / general
  • Glycoprotein implicated in apoptosis and other cellular functions
  • Strongly expressed in follicular dendritic cell tumors, weak/no expression in other dendritic cell tumors
  • Among spindle cell neoplasms, has high sensitivity and specificity for follicular dendritic cell tumors (Mod Pathol 2005;18:260)
Positive staining - disease
  • Anaplastic large cell lymphoma (80-100% of systemic cases, 40-60% of primary cutaneous cases), diffuse large B cell lymphoma (12%), carcinomas of breast, colon, pancreas, prostate