Stains
Clusterin

Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 December 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: clusterin[title]
Cite this page: Clusterin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsclusterin.html. Accessed December 8th, 2016.
Definition / General
  • Glycoprotein implicated in apoptosis and other cellular functions
  • Strongly expressed in follicular dendritic cell tumors, weak/no expression in other dendritic cell tumors
  • Among spindle cell neoplasms, has high sensitivity and specificity for follicular dendritic cell tumors (Mod Pathol 2005;18:260)
Positive Staining - Disease
  • Anaplastic large cell lymphoma (80-100% of systemic cases, 40-60% of primary cutaneous cases), diffuse large B cell lymphoma (12%), carcinomas of breast, colon, pancreas, prostate
Micro Images
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Follicular dendritic cell tumor: H&E and clusterin (b/e)