Cite this page: Clusterin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsclusterin.html. Accessed October 25th, 2016.
Definition / General
- Glycoprotein implicated in apoptosis and other cellular functions
- Strongly expressed in follicular dendritic cell tumors, weak/no expression in other dendritic cell tumors
- Among spindle cell neoplasms, has high sensitivity and specificity for follicular dendritic cell tumors (Mod Pathol 2005;18:260)
Positive Staining - Disease
- Anaplastic large cell lymphoma (80-100% of systemic cases, 40-60% of primary cutaneous cases), diffuse large B cell lymphoma (12%), carcinomas of breast, colon, pancreas, prostate