Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 17 October 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Clusterin[title]
- Glycoprotein implicated in apoptosis and other cellular functions
- Strongly expressed in follicular dendritic cell tumors, weak/no expression in other dendritic cell tumors
- Among spindle cell neoplasms, has high sensitivity and specificity for follicular dendritic cell tumors (Mod Pathol 2005;18:260)
Positive stains - disease
- Anaplastic large cell lymphoma (80-100% of systemic cases, 40-60% of primary cutaneous cases), diffuse large B cell lymphoma (12%), carcinomas of breast, colon, pancreas, prostate
Follicular dendritic cell tumor: H&E and clusterin (b/e)
End of Stains > Clusterin
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