Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 October 2015, last major update October 2013

Copyright: (c)2003-2015,, Inc.

PubMed Search: c-MET[title]
  • Gene at 7q31-34; receptor for hepatocyte growth factor receptor
  • A tyrosine kinase that mediates cell motility, proliferation, invasiveness, angiogenesis and morphogenetic differentiation
  • Activating mutations are present in papillary renal cell carcinoma; missense mutation in 6% of thyroid carcinoma (papillary, follicular and medullary, Am J Surg Pathol 2005;29:544); high levels of MET mRNA and protein expressed in papillary thyroid carcinoma
Positive Staining - Disease
  • Melanoma, melanocytic lesions