Stains
c-MET


Topic Completed: 1 October 2013

Revised: 22 April 2019

Copyright: 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: c-MET[title]

Nat Pernick, M.D.
Page views in 2018: 206
Page views in 2019 to date: 157
Cite this page: Pernick N. c-MET. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscmet.html. Accessed July 15th, 2019.
Definition / general
  • Gene at 7q31-34; receptor for hepatocyte growth factor receptor
  • A tyrosine kinase that mediates cell motility, proliferation, invasiveness, angiogenesis and morphogenetic differentiation
  • Activating mutations are present in papillary renal cell carcinoma; missense mutation in 6% of thyroid carcinoma (papillary, follicular and medullary, Am J Surg Pathol 2005;29:544); high levels of MET mRNA and protein expressed in papillary thyroid carcinoma
Positive staining - disease
  • Melanoma, melanocytic lesions
Back to top