Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 17 October 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: c-MET[title]
- Gene at 7q31-34; receptor for hepatocyte growth factor receptor
- A tyrosine kinase that mediates cell motility, proliferation, invasiveness, angiogenesis and morphogenetic differentiation
- Activating mutations are present in papillary renal cell carcinoma; missense mutation in 6% of thyroid carcinoma (papillary, follicular and medullary, Am J Surg Pathol 2005;29:544); high levels of MET mRNA and protein expressed in papillary thyroid carcinoma
Positive staining - disease
- Melanoma, melanocytic lesions
End of Stains > c-MET
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