Pathology Outlines

Stains
c-MET

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 October 2015, last major update October 2013

Copyright: (c)2003-2015, PathologyOutlines.com, Inc.

PubMed Search: c-MET[title]

Table of Contents

Definition / general | Positive staining - disease

Cite this page: c-MET. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscmet.html. Accessed July 12th, 2017.

Definition / general

Gene at 7q31-34; receptor for hepatocyte growth factor receptor
A tyrosine kinase that mediates cell motility, proliferation, invasiveness, angiogenesis and morphogenetic differentiation
Activating mutations are present in papillary renal cell carcinoma; missense mutation in 6% of thyroid carcinoma (papillary, follicular and medullary, Am J Surg Pathol 2005;29:544); high levels of MET mRNA and protein expressed in papillary thyroid carcinoma

Positive staining - disease

Melanoma, melanocytic lesions