Cite this page: Pernick N. c-MET. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscmet.html. Accessed February 27th, 2020.
Definition / general
- Gene at 7q31-34; receptor for hepatocyte growth factor receptor
- A tyrosine kinase that mediates cell motility, proliferation, invasiveness, angiogenesis and morphogenetic differentiation
- Activating mutations are present in papillary renal cell carcinoma; missense mutation in 6% of thyroid carcinoma (papillary, follicular and medullary, Am J Surg Pathol 2005;29:544); high levels of MET mRNA and protein expressed in papillary thyroid carcinoma
Positive staining - disease
- Melanoma, melanocytic lesions