Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 16 October 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Congo red[title]
- Also called amyloid stain
- Must examine stained tissue with standard and polarized light
- Amyloid under polarized light has apple green birefringence, based on the molecule being in an antiparallel beta-pleated sheet.
- Note: non-amyloid related green birefringence can occur due to excess dye retained by the tissue
Medullary carcinoma of thyroid gland-staining lower right
Amyloid in adrenal gland
Primary localized laryngeal amyloidosis (polarized light-fig F)
Amyloid tumor of breast - fig 1: coarse calcifications of right breast; 2: H&E; 3: Congo red staining; 4: Congo red under polarized light
Cardiac amyloidosis under polarized light
End of Stains > Congo red
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