- Also called amyloid stain
- Must examine stained tissue with standard and polarized light
- Amyloid under polarized light has apple green birefringence, based on the molecule being in an antiparallel beta-pleated sheet.
- Note: non-amyloid related green birefringence can occur due to excess dye retained by the tissue
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Amyloid tumor of breast - fig 1: coarse calcifications of right breast; 2: H&E; 3: Congo red staining; 4: Congo red under polarized light
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