Author: Nat Pernick, M.D.

Revised: 10 May 2018, last major update November 2014

Copyright: (c) 2003-2018,, Inc.

PubMed Search: CXCL16 title
Cite this page: Pernick, N. CXCL16. website. Accessed October 21st, 2018.
Definition / general
  • Newly identified chemokine, described in both transmembrane and soluble forms
  • CXC Chemokine Ligand 16
  • Also named SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein)
  • Receptor is CXCR6
  • Scavenger receptor which regulates inflammation, tissue injury and fibrosis
  • Involved in cell adhesion and chemoattraction; also scavenger of oxidized lipoproteins including LDL (J Neurol 2014;261:1544)
  • Transmembrane CXCL16 is expressed on surface of macrophages, dendritic cells and monocytes, where it functions as an adhesion molecule for CXCR6+ immune cells (Mediators Inflamm 2014;2014:478641)
  • Transmembrane CXCL16 undergoes cleavage by metalloproteinases ADAM10 and ADAM17 before released in soluble form to outside of cell (Mediators Inflamm 2014;2014:478641)
  • Soluble CXCL16 prompts migration of CXCR6+ leukocytes
Clinical features
Uses by pathologists
  • No specific uses at this time
Microscopic (histologic) images

Images hosted on other servers:

Cervical intraepithelial neoplasia

Meningioma (Fig 3)

Positive staining - normal
Positive staining - disease