Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 December 2015, last major update January 2012

Copyright: (c) 2003-2015,, Inc.

PubMed Search: cxcr2
Cite this page: CXCR2. website. Accessed February 24th, 2018.
Definition / general
  • Interleukin 8 receptor beta subunit (IL8RB); binds multiple CXC chemokines including IL-8 (CXCL8)
  • Chemokine receptor, powerful neutrophil chemotactic factor, particularly to sites of inflammation
  • Also called CD182; formerly called CD128b
Diagrams / tables

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Inflammatory infiltration

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Missing Image

Inflammatory infiltration

  • Cytoplasmic staining
Uses by pathologists
  • No significant uses by pathologists
Microscopic (histologic) images

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Neuroendocrine cells and neuroendocrine neoplasms

Ovarian carcinoma

Positive staining - normal
Positive staining - disease
  • Carcinoid tumor (classic, atypical, metastatic), pituitary adenoma, pheochromocytoma, medullary carcinoma
Negative staining
  • Parathyroid cells
  • Small cell carcinoma of lung/cervix, large cell lung neuroendocrine carcinoma, Merkel cell carcinoma, neuroblastoma, melanoma