Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 December 2015, last major update January 2012

Copyright: (c) 2003-2015,, Inc.

PubMed Search: cxcr2
Cite this page: CXCR2. website. Accessed April 25th, 2017.
Definition / General
  • Interleukin 8 receptor beta subunit (IL8RB); binds multiple CXC chemokines including IL-8 (CXCL8)
  • Chemokine receptor, powerful neutrophil chemotactic factor, particularly to sites of inflammation
  • Also called CD182; formerly called CD128b
Diagrams / Tables

Images hosted on other servers:

Inflammatory infiltration

Images hosted on
Missing Image

Inflammatory infiltration

  • Cytoplasmic staining
Uses by Pathologists
  • No significant uses by pathologists
Micro Images

Images hosted on other servers:


Neuroendocrine cells and neuroendocrine neoplasms

Ovarian carcinoma

Positive Staining - Normal
Positive Staining - Disease
  • Carcinoid tumor (classic, atypical, metastatic), pituitary adenoma, pheochromocytoma, medullary carcinoma
Negative Staining
  • Parathyroid cells
  • Small cell carcinoma of lung/cervix, large cell lung neuroendocrine carcinoma, Merkel cell carcinoma, neuroblastoma, melanoma