Stains
CXCR2

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 December 2015, last major update January 2012

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: cxcr2
Cite this page: CXCR2. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscxcr2.html. Accessed October 18th, 2017.
Definition / general
  • Interleukin 8 receptor beta subunit (IL8RB); binds multiple CXC chemokines including IL-8 (CXCL8)
  • Chemokine receptor, powerful neutrophil chemotactic factor, particularly to sites of inflammation
Terminology
  • Also called CD182; formerly called CD128b
Diagrams / tables

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Inflammatory infiltration



Images hosted on Nature.com:
Missing Image

Inflammatory infiltration

Interpretation
  • Cytoplasmic staining
Uses by pathologists
  • No significant uses by pathologists
Microscopic (histologic) images

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Endometrium

Neuroendocrine cells and neuroendocrine neoplasms

Ovarian carcinoma

Positive staining - normal
Positive staining - disease
  • Carcinoid tumor (classic, atypical, metastatic), pituitary adenoma, pheochromocytoma, medullary carcinoma
Negative staining
  • Parathyroid cells
  • Small cell carcinoma of lung/cervix, large cell lung neuroendocrine carcinoma, Merkel cell carcinoma, neuroblastoma, melanoma