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Stains

CXCR2

Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 25 January 2012, last major update December 2011
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

General
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● Interleukin 8 receptor beta subunit (IL8RB); binds multiple CXC chemokines including IL-8 (CXCL8)
● Chemokine receptor, powerful neutrophil chemotactic factor, particularly to sites of inflammation

Terminology
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● Also called CD182; formerly called CD128b

Diagrams
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Inflammatory infiltration

Interpretation
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● Cytoplasmic staining

Uses by Pathologists
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● No significant uses by pathologists

Micro images
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Endometrium


Neuroendocrine cells and neuroendocrine neoplasms


Ovarian carcinoma

Positive staining - normal
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● Mature granulocytes, keratinocytes, neuroendocrine cells, projection neurons (Arch Pathol Lab Med 2000;124:520)

Positive staining - disease
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● Carcinoid tumor (classic, atypical, metastatic), pituitary adenoma, pheochromocytoma, medullary carcinoma

Negative staining
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● Parathyroid cells
● Small cell carcinoma of lung/cervix, large cell lung neuroendocrine carcinoma, Merkel cell carcinoma, neuroblastoma, melanoma

End of Stains > CXCR2

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