Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 18 October 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: CXCR3[title]
- Also called CD183
- Receptor for some chemokines; binding of chemokines to CD183 induces integrin activation, cytoskeletal changes and chemotactic migration in inflammation-associated effector T cells
- CD183+ T cells detected in inflamed tissues of patients with juvenile rheumatoid arthritis, multiple sclerosis, sarcoidosis, hepatitis C
Positive staining - normal
- T cells in inflamed tissue, eosinophils, plasmacytoid dendritic cells, hematopoietic progenitors
- Na´ve T cells in peripheral blood
End of Stains > CXCR3
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