Topic Completed: 1 October 2013

Revised: 18 December 2018, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: cxcr3[title]

Nat Pernick, M.D.
Page views in 2018: 66
Page views in 2019 to date: 41
Cite this page: Pernick N. CXCR3. website. Accessed September 23rd, 2019.
Definition / general
  • Also called CD183
  • Receptor for some chemokines; binding of chemokines to CD183 induces integrin activation, cytoskeletal changes and chemotactic migration in inflammation-associated effector T cells
  • CD183+ T cells detected in inflamed tissues of patients with juvenile rheumatoid arthritis, multiple sclerosis, sarcoidosis, hepatitis C
Positive staining - normal
  • T cells in inflamed tissue, eosinophils, plasmacytoid dendritic cells, hematopoietic progenitors
Negative staining
  • Na├»ve T cells in peripheral blood
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