Topic Completed: 1 October 2013

Minor changes: 2 June 2020

Revised: 18 December 2018, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: cxcr3[title]

Nat Pernick, M.D.
Page views in 2019: 57
Page views in 2020 to date: 49
Cite this page: Pernick N. CXCR3. website. Accessed August 4th, 2020.
Definition / general
  • Also called CD183
  • Receptor for some chemokines; binding of chemokines to CD183 induces integrin activation, cytoskeletal changes and chemotactic migration in inflammation-associated effector T cells
  • CD183+ T cells detected in inflamed tissues of patients with juvenile rheumatoid arthritis, multiple sclerosis, sarcoidosis, hepatitis C
Positive staining - normal
  • T cells in inflamed tissue, eosinophils, plasmacytoid dendritic cells, hematopoietic progenitors
Negative staining
  • Na├»ve T cells in peripheral blood
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