Stains
CXCR3

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 December 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: cxcr3[title]
Cite this page: CXCR3. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscxcr3.html. Accessed December 4th, 2016.
Definition / General
  • Also called CD183
  • Receptor for some chemokines; binding of chemokines to CD183 induces integrin activation, cytoskeletal changes and chemotactic migration in inflammation-associated effector T cells
  • CD183+ T cells detected in inflamed tissues of patients with juvenile rheumatoid arthritis, multiple sclerosis, sarcoidosis, hepatitis C
Positive Staining - Normal
  • T cells in inflamed tissue, eosinophils, plasmacytoid dendritic cells, hematopoietic progenitors
Negative Staining
  • Na├»ve T cells in peripheral blood