Stains
CXCR5

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 December 2015, last major update December 2011

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: cxcr5
Cite this page: CXCR5. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscxcr5.html. Accessed December 9th, 2016.
Definition / General
  • Multi-pass membrane protein of CXC chemokine receptor family
Terminology
  • Also called CD185, BLR1 (Burkitt lymphoma receptor 1)
Pathophysiology
  • Binds to B Lymphocyte Chemoattractant (BLC / CXCL13, J Exp Med 1998;187:655); involved in B cell migration into B cell follicles of spleen and Peyer patches (J Immunol 2009;182:2610)
  • Critical for function of follicular helper T (TFH) cells
  • May have role in survival and maintainance of cardiac structure upon pressure overload by regulating proteoglycans essential for correct collagen assembly (PLoS One 2011;6:e18668)
  • May be important for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori induced inflammation (J Mol Med (Berl) 2010;88:1169)
  • During HIV1 infection, altered expression of CXCR5/CXCL13 may cause B cell dysfunction (Blood 2008;112:4401)
  • Upregulated in rheumatoid arthritis synovial tissue and expressed in various cell types (Arthritis Res Ther 2005;7:R217)
Interpretation
  • Cytoplasmic staining
Uses by Pathologists
  • No significant uses by pathologists
Micro Images

Left: chronic H. pylori gastris (fig F); right: MALT lymphoma (fig E)

AIDS related non-Hodgkin lymphoma is CXCR5+

Synovium of non-rheumatoid arthritis (left) and rheumatoid arthritis (right)

Positive Staining - Normal
  • Mature B cells
Positive Staining - Disease