Reviewer: Nat Pernick, M.D., PathologyOutlines.com, Inc. (see Reviewers page)
Revised: 14 December 2011, last major update December 2011
Copyright: (c) 2011, PathologyOutlines.com, Inc.
● Multi-pass membrane protein of CXC chemokine receptor family
● Also called CD185, BLR1 (Burkitt lymphoma receptor 1)
● Binds to B Lymphocyte Chemoattractant (BLC / CXCL13, J Exp Med 1998;187:655); involved in B cell migration into B cell follicles of spleen and Peyer patches (J Immunol 2009;182:2610)
● Critical for function of follicular helper T (TFH) cells
● May have role in survival and maintainance of cardiac structure upon pressure overload by regulating proteoglycans essential for correct collagen assembly (PLoS One 2011;6:e18668)
● May be important for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori induced inflammation (J Mol Med (Berl) 2010;88:1169)
● During HIV1 infection, altered expression of CXCR5/CXCL13 may cause B cell dysfunction (Blood 2008;112:4401)
● Upregulated in rheumatoid arthritis synovial tissue and expressed in various cell types (Arthritis Res Ther 2005;7:R217)
● Cytoplasmic staining
Uses by Pathologists
● No significant uses by pathologists
Left: chronic H. pylori gastris (fig f); right: MALT lymphoma (fig e)
AIDS related non-Hodgkin lymphoma is CXCR5+
Synovium of non-rheumatoid arthritis (left) and rheumatoid arthritis (right)
Positive staining - normal
● Mature B cells
Positive staining - disease
● Burkitt's lymphoma, mantle cell lymphoma (Blood 2009;113:4604); AIDS-related non-Hodgkin lymphoma (AIDS Res Treat 2010;2010:164586)
End of Stains > CXCR5
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