Cyclooxygenase 2 (COX2)

Author: Nat Pernick, M.D.

Revised: 10 May 2018, last major update October 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Cox2[title] "loattrfree full text"[sb]
Cite this page: Pernick, N. Cyclooxygenase 2 (COX2). website. Accessed October 22nd, 2018.
Definition / general
  • Not related to Cytochrome c oxidase (COX)
  • Cyclooxygenases 1 (COX1) and 2 (COX2), also known as prostaglandin H synthase, catalyze formation of prostaglandin from arachidonic acid
  • COX1 is constitutive form of enzyme on 9q; COX2 is inducible isoform on 1q, has 61% sequence homology with COX1
  • Regulated by mitogens, tumor promoters, cytokines, serum, free fatty acids, NSAIDs, selective COX2 inhibitors
  • Increased expression associated with poor clinical outcome in stage I/II non-small cell lung carcinoma (Arch Pathol Lab Med 2005;129:1113), possibly poorer outcome in follicular thyroid carcinoma (Arch Pathol Lab Med 2005;129:736)
  • Cytoplasmic staining
Positive staining - normal
  • Endothelial cells
Positive staining - disease
  • Breast, colorectal, esophageal, liver, lung, ovary, pancreas, prostate, skin, stomach tumors
Microscopic (histologic) images

Images hosted on other servers:

Lung adenocarcinoma
(A: COX2+; B: COX2-;
C: endothelial cells
are positive control)

Fig 7-staining in follicular carcinoma