Stains
Cyclooxygenase 2 (COX2)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 December 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: cox2[title]
General
  • Cyclooxygenases 1 (COX1) and 2 (COX2), also known as prostaglandin H synthase, catalyze formation of prostaglandin from arachidonic acid
  • COX1 is constitutive form of enzyme on 9q; COX2 is inducible isoform on 1q, has 61% sequence homology with COX1
  • Regulated by mitogens, tumor promoters, cytokines, serum, free fatty acids, NSAIDs, selective COX2 inhibitors
  • Increased expression associated with poor clinical outcome in stage I/II non-small cell lung carcinoma (Arch Pathol Lab Med 2005;129:1113), possibly poorer outcome in follicular thyroid carcinoma (Arch Pathol Lab Med 2005;129:736)
Interpretation
  • Cytoplasmic staining
Positive Staining - Normal
  • Endothelial cells
Positive Staining - Disease
  • Breast, colorectal, esophageal, liver, lung, ovary, pancreas, prostate, skin, stomach tumors
Micro Images

Images hosted on other servers:

Lung adenocarcinoma (A: COX2+; B: COX2-; C: endothelial cells are positive control)


Fig 7-staining in follicular carcinoma

Diagrams / Tables

Arachidonic acid pathway