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Stains

DBA-44


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 18 December 2012, last major update February 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

Definition
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● Antibody raised against B cell centroblastic cell line
● Also written as DBA.44, DBA44
● Does not appear to be the same antibody as CD72 - Am J Surg Pathol 1996;20:613 is apparently wrong

Uses by pathologists
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● Sensitive and relatively specific for hairy cell lymphoma when combined with tartrate-resistant phosphatase positivity (Am J Surg Pathol 2005;29:474)

Micro images
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Hairy cell leukemia-cecum

Positive staining - normal
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● Mantle zone of hyperplastic follicles

Positive staining - disease
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● Hairy cell leukemia (particularly “hairy” cytoplasmic processes)
● Splenic margin zone lymphoma (71%, Am J Surg Pathol 2007;31:438)
● Follicular center cell lymphomas (46%)
● High grade B cell lymphomas

Negative staining
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● CLL

End of Stains > DBA-44


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