deltaNp63 (p40)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 2 December 2015, last major update January 2012

Copyright: (c) 2002-2015,, Inc.

PubMed Search: deltaNp63 [title]

Cite this page: deltaNp63. website. Accessed October 25th, 2016.
Definition / General
  • One of 10 p63 isoforms (J Virol 2007;81:11569), important to classify non small cell lung cancer into adenocarcinoma (p40-) versus squamous cell carcinoma (p40+), which determines chemotherapy regimen
  • Truncated, nontransactivating isoform highly specific for squamous / basal cells
Clinical Features
  • Mutations cause ectrodactyly-ectodermal dysplasia-cleft syndrome, ankyloblepharon-ectodermal dysplasia-clefting syndrome, nonsyndromic split-hand/split-foot malformation (J Cell Sci 2011;124:2200)
Uses by Pathologists
Micro Images

Images hosted on Other servers:

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Hidradenocarcinoma, metastatic to lymph node

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Lung, various tumors

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Oral preneoplastic lesions (OPL)

Nature images:

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Pancreas, various images

Positive Staining - Normal
Positive Staining - Disease
Negative Staining