Stains & molecular markers
deltaNp63 (p40)


Topic Completed: 1 January 2012

Minor changes: 5 February 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: deltaNp63 [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. deltaNp63. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsdeltaNp63.html. Accessed August 7th, 2020.
Definition / general
  • One of 10 p63 isoforms (J Virol 2007;81:11569), important to classify non small cell lung cancer into adenocarcinoma (p40-) versus squamous cell carcinoma (p40+), which determines chemotherapy regimen
  • Truncated, nontransactivating isoform highly specific for squamous / basal cells
Terminology
Clinical features
  • Mutations cause ectrodactyly-ectodermal dysplasia-cleft syndrome, ankyloblepharon-ectodermal dysplasia-clefting syndrome, nonsyndromic split-hand/split-foot malformation (J Cell Sci 2011;124:2200)
Uses by pathologists
Microscopic (histologic) images

Contributed by Andrey Bychkov, M.D., Ph.D.

Lung SCC



Images hosted on other servers:
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Hidradeno-carcinoma, metastatic to lymph node

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Lung, various tumors

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Oral preneoplastic lesions (OPL)

Positive staining - normal
Positive staining - disease
Negative staining
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