deltaNp63 (p40)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 19 November 2018, last major update January 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: deltaNp63 [title]

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Cite this page: Pernick, N. deltaNp63. website. Accessed January 23rd, 2019.
Definition / general
  • One of 10 p63 isoforms (J Virol 2007;81:11569), important to classify non small cell lung cancer into adenocarcinoma (p40-) versus squamous cell carcinoma (p40+), which determines chemotherapy regimen
  • Truncated, nontransactivating isoform highly specific for squamous / basal cells
Clinical features
  • Mutations cause ectrodactyly-ectodermal dysplasia-cleft syndrome, ankyloblepharon-ectodermal dysplasia-clefting syndrome, nonsyndromic split-hand/split-foot malformation (J Cell Sci 2011;124:2200)
Uses by pathologists
Microscopic (histologic) images

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Hidradeno-carcinoma, metastatic to lymph node

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Lung, various tumors

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Oral preneoplastic lesions (OPL)

Positive staining - normal
Positive staining - disease
Negative staining