Stains
Dicer

Author: Rebecca Obeng, M.D. (see Authors page)

Revised: 15 July 2016, last major update July 2016

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Dicer [title]

Cite this page: Dicer. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsdicer.html. Accessed May 23rd, 2017.
Definition / general
  • Protein encoded by DICER1 gene on chromosome 14
  • A ribonuclease that produces 21 - 23 nucleotide short interfering RNAs (siRNAs) and microRNAs (miRNAs) by cleaving long double stranded RNAs (dsRNAs) and pre-miRNAs
Essential features
Terminology
  • Dicer 1, ribonuclease III, Dcr-1 homolog, helicase MOI, HERNA, helicase with RNA motif, Double stranded RNA specific endoribonuclease
Epidemiology
  • The prevalence and penetrance of the mutations are not known
  • Dicer syndrome is a rare disorder
Sites
  • Ubiquitously expressed
Pathophysiology
Etiology
  • Unknown
Clinical features
  • Depends on the neoplastic process
Diagnosis
  • The levels of dicer may be useful in the diagnosis of cancer
  • Decreased expression identified in patients with tumors (Cancer Res 2010;70:2571)
Radiology description
  • Radiologic features depends on the presenting disease
Prognostic factors
Case reports
Treatment
  • Depends on the present disease
  • Surgical resection with or without chemotherapy
  • Patients with pleuropulmonary blastoma may also undergo radiation therapy
Microscopic (histologic) description
  • Cytoplasmic staining
Microscopic (histologic) images

Images hosted on other servers:

Dicer expression in benign prostatic epithelium

Expression in urinary bladder

Expression of dicer in neoplastic prostate tissue

Positive stains
Negative stains
Molecular / cytogenetics description
  • Deletions, insertions, missense mutations, nonsense mutations, splice variants