Stains
DOG1



Topic Completed: 1 November 2011

Revised: 5 March 2019

Copyright: 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: DOG1 [title]
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Cite this page: Pernick N. DOG1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsdog1.html. Accessed March 25th, 2019.
Definition / general
  • Discovered On GIST 1
  • Chloride channel protein
Interpretation
  • Membranous and cytoplasmic staining
Uses by pathologists
Microscopic (histologic) images

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GIST

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GIST: p16, DOG1 and PDGFRA

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GIST and other tumors

Positive staining - normal
Positive staining - disease
  • GIST, pancreatic solid-pseudopapillary neoplasm (Hum Pathol 2011;42:817)
  • Often esophageal squamous cell and gastric carcinomas
    • Occasionally uterine type retroperitoneal leiomyomas colonized by DOG1+ Cajal cells, peritoneal leiomyomatosis, synovial sarcomas (Am J Surg Pathol 2009;33:1401)
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