Stains - Dynactin1

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Stains

Dynactin1

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 24 November 2012, last major update November 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

Definition
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● Also called DCTN1
● Dynactin is largest of 10 subunits that make up a complex involved in: ER-Golgi transport, centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, axonogenesis, retrograde axonal transport (Neuropathology 2012;32:458); complex binds to Dynein intermediate chain (Cell migration consortium)
● Mutations cause Perry syndrome (Parkinsonism Relat Disord 2010;16:612, Nat Genet 2009;41:163, Perry Syndrome: Gene Reviews™ [Internet], University of Washington)
● Mutations are only occasionally associated with ALS (Neurology 2009;72:2024, J Neuropathol Exp Neurol 2007;66:617), frontal temporal dementia and motor neuron disease (J Neurosci 2010;30:13729)
● Case report of 7 year old girl with inflammatory myofibroblastic tumor; FISH/PCR confirms fusion of dynactin 1 and anaplastic lymphoma kinase genes (Hum Pathol 2012;43:2047)

Dynactin protein complex

Uses by pathologists
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● No specific uses at this time

Micro images
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Perry syndrome

Positive staining - normal
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● Dynactin subunits p50 and p62 are useful for immunohistochemistry; Dynactin p150 is not

End of Stains > Dynactin1

Ref Updated: 11/23/12

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