Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 2 October 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: E2A[title]
See below: E2A-PBX1
- Transcriptional factor at 19p13.3 that binds DNA
- Fusion protein found in 25% of early pre-B ALL, 5-7% of pediatric ALL via t(1;19)(q23;p13)
- N terminal of protein has E2A, C terminal has PBX-1
- Transcriptional transactivator; precise mechanism not known
- Poor prognostic factor in childhood ALL, although some t(1;19) translocations in pediatric ALL lack E2A-PBX1 expression and have better prognosis
- Associated with L1 subtype of ALL; positive for CD9, CD10, CD19
End of Stains > E2A
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