Stains
E2A



Topic Completed: 1 June 2005

Revised: 5 March 2019

Copyright: 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: E2A [title]
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Table of Contents
Definition / general | See also
Cite this page: Pernick N. E2A. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainse2a.html. Accessed May 24th, 2019.
Definition / general
  • Transcriptional factor at 19p13.3 that binds DNA
See also
E2A-PBX1
General:
  • Fusion protein found in 25% of early pre-B ALL, 5-7% of pediatric ALL via t(1;19)(q23;p13)
  • N terminal of protein has E2A, C terminal has PBX-1
  • Transcriptional transactivator
    • Precise mechanism not known
  • Poor prognostic factor in childhood ALL, although some t(1;19) translocations in pediatric ALL lack E2A-PBX1 expression and have better prognosis
  • Associated with L1 subtype of ALL; positive for CD9, CD10, CD19
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