Pathology Outlines

Stains
E2A

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 December 2015, last major update June 2005

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: E2A [title]

Table of Contents

Definition / general | See also

Cite this page: E2A. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainse2a.html. Accessed July 12th, 2017.

Definition / general

Transcriptional factor at 19p13.3 that binds DNA

See also

E2A-PBX1
General:

Fusion protein found in 25% of early pre-B ALL, 5-7% of pediatric ALL via t(1;19)(q23;p13)
N terminal of protein has E2A, C terminal has PBX-1
Transcriptional transactivator
- Precise mechanism not known
Poor prognostic factor in childhood ALL, although some t(1;19) translocations in pediatric ALL lack E2A-PBX1 expression and have better prognosis
Associated with L1 subtype of ALL; positive for CD9, CD10, CD19