Stains
E-cadherin


Topic Completed: 1 June 2005

Revised: 20 September 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: E-cadherin [title]

Nat Pernick, M.D.
Page views in 2018: 7,158
Page views in 2019 to date: 8,353
Cite this page: Pernick N. E-cadherin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsecadherin.html. Accessed December 13th, 2019.
Definition / general
  • "Epithelial calcium-dependent cell adhesion protein"
  • Calcium dependent transmembrane epithelial protein that promotes intercellular adhesion
  • Its loss is associated with invasive carcinoma
  • Tumor suppressor gene CDH1 is at 16q22.1
  • Abnormal function in carcinomas may facilitate cellular detachment leading to metastasis
  • Interpretation: normal pattern is membranous staining
  • Bladder: reduced expression in invasive bladder carcinoma
  • Breast cancer: absent expression in lobular carcinoma and LCIS
  • Stomach: signet ring carcinomas is negative for E-cadherin expression
  • Colonic adenocarcinoma: diminished membranous staining compared to adenomas with misplaced epithelium (Am J Surg Pathol 2002;26:206)
Uses by pathologists
Microscopic (histologic) images

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Paget disease, nipple

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