Stains
EGFR

Author: Nat Pernick, M.D. (see Authors page)

Revised: 1 August 2018, last major update June 2005

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: EGFR [title]

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Cite this page: Pernick, N. EGFR. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsegfr.html. Accessed January 22nd, 2019.
Definition / general
  • Epidermal Growth Factor Receptor
    • Also called HER1, c-erb-B1; on 7p
  • Member of epidermal growth factor receptor family (also HER2)
  • 170 kDa transmembrane receptor that induces tyrosine kinase activity affecting cell growth
  • Activated by epidermal growth factor and transforming growth factor alpha
  • Lung adenocarcinoma patients with specific mutations may have clinical response to gefitinib (targets EGFR kinase)
  • Brain: amplification is favorable prognostic factor in glioblastoma multiforme (Arch Pathol Lab Med 2005;129:624)
  • Breast: 6% of breast carcinomas show EGFR amplification (7 - 18 copies) associated with EGRF protein overexpression but not HER2 status
  • Colon: present in 60 - 80% of colorectal carcinomas but these tumors lack gene amplification (Mod Pathol 2005;18:1350) and patients don't respond to gefitinib
  • Lung: mutations are associated with terminal respiratory unit type adenocarcinoma of lung (Am J Surg Pathol 2005;29:633)
    • EGRF tyrosine kinase inhibitors (gefitinib) show rapid clinical response in 10% of lung cancer patients
Microscopic (histologic) images

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Colorectal carcinoma

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Chromogenic in situ hybridization

Positive staining - normal
  • Endometrial stromal cells
Positive staining - disease
  • Endometrial stromal sarcoma (Am J Surg Pathol 2005;29:485)
  • Adenosarcoma, MMMT, squamous cell carcinoma of lung, 80% of non-small cell lung cancers
Molecular / cytogenetics images

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Amplification by FISH