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Definition / general | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: EGFR. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsegfr.html. Accessed July 12th, 2017.
Definition / general
- Epidermal Growth Factor Receptor
- Also called HER1, c-erb-B1; on 7p
- Member of epidermal growth factor receptor family (also HER2)
- 170 kDa transmembrane receptor that induces tyrosine kinase activity affecting cell growth
- Activated by epidermal growth factor and transforming growth factor alpha
- Lung adenocarcinoma patients with specific mutations may have clinical response to gefitinib (targets EGFR kinase)
- Brain: amplification is favorable prognostic factor in glioblastoma multiforme (Arch Pathol Lab Med 2005;129:624)
- Breast: 6% of breast carcinomas show EGFR amplification (7 - 18 copies) associated with EGRF protein overexpression but not HER2 status
- Patients may be responsive to EGFR therapy (Mod Pathol 2005;18:1027)
- Colon: present in 60-80% of colorectal carcinomas, but these tumors lack gene amplification (Mod Pathol 2005;18:1350), and patients don’t respond to gefitinib
- Lung: mutations are associated with terminal respiratory unit type adenocarcinoma of lung (Am J Surg Pathol 2005;29:633)
- EGRF tyrosine kinase inhibitors (gefitinib) show rapid clinical response in 10% of lung cancer patients
Microscopic (histologic) images
Images hosted on Other servers:
Amplification by FISH
Nature images:
Breast carcinoma
Colorectal carcinoma
Chromogenic in situ hybridization
Positive staining - normal
- Endometrial stromal cells
Positive staining - disease
- Endometrial stromal sarcoma (Am J Surg Pathol 2005;29:485)
- Adenosarcoma, MMMT, squamous cell carcinoma of lung, 80% of non-small cell lung cancers
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