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Stains

eIF-4F


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 21 April 2012, last major update April 2012-IN PROGRESS
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

Definition
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● Eukaryotic initiation factor 4F mediates the initiation of cellular mRNA translation (EMBO J 2008;27:3129)
● eIF-4F activity is controlled by a repressor binding protein (4E-BP1), which promotes translation when phosphorylated (Arch Pathol Lab Med 2011;135:365)

Diagrams
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A simplified view of eukaryotic translation initiation.


Phosphorylation status of 4E-BP1 regulates cap-dependent translation initiation

Uses by pathologists
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● None at this time

End of Stains > eIF-4F

Ref Updated: 4/2/12


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