Stains
Elongin

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 December 2015, last major update June 2005

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: Elongin [title]

Table of Contents
Definition / General
Definition / General
  • Transcription elongation factor; negatively regulated by von Hippel Lindau protein
  • Increases rate of elongation by suppressing RNA polymerase pausing
  • Heterotrimer of A, B and C subunits
  • VHL product competes with subunit A for binding with BC, causing more "pausing", less transcription
    • Catalytic subunit of ABC complex
      • Competes with VHL for binding of Elongin (homologous coding region)
    • Positive regulator of Elongin
    • Positive regulator of Elongin
      • Similar to E. coli termination factor Rho's RNA binding region, so binding of nascent RNA may be important