Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 2 October 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Elongin[title]
- Transcription elongation factor; negatively regulated by von Hippel Lindau protein
- Increases rate of elongation by suppressing RNA polymerase pausing
- Heterotrimer of A, B and C subunits
- VHL product competes with subunit A for binding with BC, causing more "pausing", less transcription
A. Catalytic subunit of ABC complex; competes with VHL for binding of Elongin (homologous coding region)
B. Positive regulator of Elongin
C. Positive regulator of Elongin; similar to E. coli termination factor Rho's RNA binding region, so binding of nascent RNA may be important
End of Stains > Elongin
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