Pathology Outlines

Stains
Elongin

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 December 2015, last major update June 2005

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: Elongin [title]

Table of Contents

Definition / general

Cite this page: Elongin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainselongin.html. Accessed July 12th, 2017.

Definition / general

Transcription elongation factor; negatively regulated by von Hippel Lindau protein
Increases rate of elongation by suppressing RNA polymerase pausing
Heterotrimer of A, B and C subunits
VHL product competes with subunit A for binding with BC, causing more "pausing", less transcription
- Catalytic subunit of ABC complex
  - Competes with VHL for binding of Elongin (homologous coding region)
- Positive regulator of Elongin
- Positive regulator of Elongin
  - Similar to E. coli termination factor Rho's RNA binding region, so binding of nascent RNA may be important