Topic Completed: 1 June 2005

Revised: 5 March 2019

Copyright: 2002-2015,, Inc.

PubMed Search: Elongin [title]

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. Elongin. website. Accessed February 19th, 2020.
Definition / general
  • Transcription elongation factor; negatively regulated by von Hippel Lindau protein
  • Increases rate of elongation by suppressing RNA polymerase pausing
  • Heterotrimer of A, B and C subunits
  • VHL product competes with subunit A for binding with BC, causing more "pausing", less transcription
    • Catalytic subunit of ABC complex
      • Competes with VHL for binding of Elongin (homologous coding region)
    • Positive regulator of Elongin
    • Positive regulator of Elongin
      • Similar to E. coli termination factor Rho's RNA binding region, so binding of nascent RNA may be important
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