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Definition
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Uses by pathologists
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Micro images
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Basaloid squamous cell carcinoma is BerEP4+

Breast: ductal and lobular carcinoma - primary and metastases (EpCAM)

Breast cancer: increased EpCAM expression in metastases


Colon: loss of EPCAM expression in cancers associated with Lynch syndrome caused by heterozygous EPCAM germline deletions


Esophagus: normal and Barrett's metaplasia; gastric mucosa

Ovarian serous carcinoma is MOC31+ (fig E); lung adenocarcinoma is BerEP4+ (fig F)

Unknown site: adenocarcinoma (MOC31)

Cytology images
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Reactive mesothelial cells (BerEP4 / MOC31 negative) versus metastatic adenocarcinoma (positive)

Positive staining - normal
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Positive staining - disease
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Negative staining
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End of Stains > BerEP4 / EpCAM



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