Stains
ETS1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 December 2015, last major update June 2005

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: ETS1 [title]

Table of Contents
Definition / General
Definition / General
  • Proto-oncogene at 11q23-24, also called v-ets
  • Member of Erythroblastosis virus association Transforming Sequence family of DNA binding transcription factors, all with a common 84 amino acid sequence called Ets domain
    • Also a specific transcription factor
  • Activates transcription of urokinase-plasminogen activator, MMP1, MMP3, MMP9, all associated with metastases
  • Present in both tumor and stromal cells
  • Expression induced by acidic and basic vascular endothelial growth factor, vascular endothelial growth factor, epidermal growth factor
  • Ovary: mRNA expression in solid ovarian carcinomas and effusions of serous ovarian carcinoma is poor prognostic marker (Am J Surg Pathol 2001;25:1493)