Advertisement
Advertisement
Table of Contents
Definition / generalCite this page: ETS1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsets1.html. Accessed July 12th, 2017.
Definition / general
- Proto-oncogene at 11q23-24, also called v-ets
- Member of Erythroblastosis virus association Transforming Sequence family of DNA binding transcription factors, all with a common 84 amino acid sequence called Ets domain
- Also a specific transcription factor
- Activates transcription of urokinase-plasminogen activator, MMP1, MMP3, MMP9, all associated with metastases
- Present in both tumor and stromal cells
- Expression induced by acidic and basic vascular endothelial growth factor, vascular endothelial growth factor, epidermal growth factor
- Ovary: mRNA expression in solid ovarian carcinomas and effusions of serous ovarian carcinoma is poor prognostic marker (Am J Surg Pathol 2001;25:1493)
Advertisement
