Topic Completed: 1 June 2005

Minor changes: 5 March 2019

Copyright: 2002-2015,, Inc.

PubMed Search: ETS1 [title]

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. ETS1. website. Accessed May 30th, 2020.
Definition / general
  • Proto-oncogene at 11q23-24, also called v-ets
  • Member of Erythroblastosis virus association Transforming Sequence family of DNA binding transcription factors, all with a common 84 amino acid sequence called Ets domain
    • Also a specific transcription factor
  • Activates transcription of urokinase-plasminogen activator, MMP1, MMP3, MMP9, all associated with metastases
  • Present in both tumor and stromal cells
  • Expression induced by acidic and basic vascular endothelial growth factor, vascular endothelial growth factor, epidermal growth factor
  • Ovary: mRNA expression in solid ovarian carcinomas and effusions of serous ovarian carcinoma is poor prognostic marker (Am J Surg Pathol 2001;25:1493)
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