Home
Chapter Home
Jobs
Conferences
Fellowships
Books
Advertisement
Stains
EWS
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 1 October 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: EWS[title]
See below: EWS/FLI1
EWS-WT1
General
=========================================================================
- At 22q12
- Translocations:
- t(9;22)(q22;q12) with TEC gene on #9 in myxoid chondrosarcoma
- t(11;22)(p13;q12) in desmoplastic small round cell tumor with WT1 gene on #11
- t(11;22)(q24;q12) in Ewing sarcoma/PNET
EWS/FLI1
General
=========================================================================
- Fusion protein of Ewing sarcoma/PNET localized to nucleus, associated with t(11;22)(q24;q12)
- More powerful transcription activator than normal FLI1, can transform NIH 3T3 cells
EWS-WT1
General
=========================================================================
- Fusion protein of desmoplastic small round cell tumor, associated with t(11;22)(p13;q12)
- Fusion gene may lose the tumor suppressor effect of WT1 and gain the transactivation activity of EWS, functioning as a novel transcription factor that activates expression of target genes normally repressed by WT1, such as PDGF-A
End of Stains > EWS
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com
with any questions (click here for other
contact information).