Stains
EWSR1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 December 2015, last major update October 2013

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: EWSR1 [title]

Definition / General
  • Ewing sarcoma breakpoint region 1
    • At 22q12
  • Involved in transcriptional regulation for specific genes and in mRNA splicing
    • Plays a role in transcription initiation
  • Common fusion partner involved in various tumors (Med Oncol 2013;30:412)
Interpretation
EWSR1 translocations:
Diagrams / Tables

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Schematic of EWS gene

Clinical Features
  • EWSR1 binds hepatitis C virus cis-acting replication element (CRE) and is required for efficient viral replication (J Virol 2013;87:6625)
  • May exhibit cytoplasmic mislocalization in amyotrophic lateral sclerosis (Hum Mol Genet 2012;21:2899)
Micro Images

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Spinal cord of ALS patients

Molecular / Cytogenetics Images

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Bone, Ewing/PNET c/o Mark R. Wick, M.D.



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Tongue



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CNS

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Skin, myoepithelioma