Stains
Factor VIII related antigen

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 December 2015, last major update July 2012

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: Factor VIII related antigen
Definition / General
  • Interpretation: cytoplasmic stain; endothelium acts as a positive internal control
Uses by Pathologists
  • Common endothelial marker
Micro Images

Images hosted on other servers:

Capillary hemangioma of endometrium (fig 2B)


Cribriform DCIS of breast - fig 2a: factor VIII staining shows only rare vascular proliferation; 2b: low MIB1 staining

Positive Staining - Normal
  • Endothelial cells, megakaryocytes, platelets and mast cells
Positive Staining - Disease
  • Vascular tumors