Topic Completed: 1 October 2013

Minor changes: 31 August 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Fascin[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Fascin. website. Accessed October 29th, 2020.
Definition / general
  • 55 kDa protein that forms tight and stable cytoplasmic bundles with filamentous actin
  • Fascin-1: most common type; present in specialized cells with extensive surfaces or migratory potential, such as neurons, glia, dendritic cells, macrophages, skeletal and smooth muscle, endothelial cells; not normal epithelial cells
  • Fascin-2: in retina
  • Fascin-3: in testis
  • Actin bundling protein with important role in cell motility and adhesion
  • Overexpression in tumors often associated with aggressive disease
Positive staining - disease
  • Carcinoma of biliary tract, breast, colon, lung, ovary, pancreas, skin
  • Follicular dendritic cell tumors, Hodgkin lymphoma-classic subtype (highly sensitive)
  • Interdigitating dendritic cell tumors, Langerhan cell histiocytosis, urothelial carcinoma (noninvasive papillary or invasive)
Negative staining
  • Normal epithelial cells, normal urothelium, benign urothelial lesions
Additional references
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