Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 December 2015, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Fascin[title]
Cite this page: Fascin. website. Accessed October 21st, 2016.
Definition / General
  • 55 kDa protein that forms tight and stable cytoplasmic bundles with filamentous actin
  • Fascin-1: most common type; present in specialized cells with extensive surfaces or migratory potential, such as neurons, glia, dendritic cells, macrophages, skeletal and smooth muscle, endothelial cells; not normal epithelial cells
  • Fascin-2: in retina
  • Fascin-3: in testis
  • Actin bundling protein with important role in cell motility and adhesion
  • Overexpression in tumors often associated with aggressive disease
Positive Staining - Disease
  • Carcinoma of biliary tract, breast, colon, lung, ovary, pancreas, skin
  • Follicular dendritic cell tumors, Hodgkin lymphoma-classic subtype (highly sensitive)
  • Interdigitating dendritic cell tumors, Langerhan cell histiocytosis, urothelial carcinoma (noninvasive papillary or invasive)
Negative Staining
  • Normal epithelial cells, normal urothelium, benign urothelial lesions
Micro Images

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Synovial sarcoma (positive)

Additional References