FGFR3 (CD333)

Topic Completed: 1 November 2012

Revised: 20 December 2018, last major update November 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: FGFR3 [title]

Nat Pernick, M.D.
Page views in 2018: 103
Page views in 2019 to date: 51
Cite this page: Pernick N. FGFR3. website. Accessed July 21st, 2019.
Definition / general
Uses by pathologists
  • For non muscle invasive urothelial carcinoma, surveillance with FGFR3 mutation analysis on urine to partially replace cystoscopy may be cost-effective (J Urol 2013;189:1676)
  • Help diagnose upper urinary tract urothelial carcinoma (BMC Urol 2012;12:20)
  • Help diagnose (with ultrasound) FGFR3-related skeletal dysplasias in utero
Diagrams / tables

Images hosted on other servers:

FGFR3 and downstream pathways

t(4;14) in myeloma

Microscopic (histologic) images

Images hosted on other servers:

Bladder: urothelial carcinoma

Pancreas: strong cytoplasmic staining of islets but not glandular epithelium or ducts (Fig 7A)

Salivary gland (Fig 8A)

Skin: malignant acanthosis nigricans
(a) Internal root sheath of normal hair follicle (positive control)
(b) Axillary skin in malignant acanthosis nigricans
(c) Verrucous plaque

Positive staining - normal
  • Pancreatic islets (not acini, not ducts)
  • Salivary gland-sublingual (ducts, not epithelial cells)
  • Skin: normal hair follicle
Positive staining - disease
  • Prostate: nodular hyperplasia, adenocarcinoma
  • Skin: malignant acanthosis nigricans, seborrheic keratoses
  • Urothelial carcinoma (low grade, occasionally high grade), urothelial papilloma (classic, inverted)
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