FGFR3 (CD 333)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 December 2015, last major update November 2012

Copyright: (c) 2003-2015,, Inc.

PubMed Search: FGFR3 [title]
Cite this page: FGFR3. website. Accessed May 27th, 2018.
Definition / general
Uses by pathologists
  • For non muscle invasive urothelial carcinoma, surveillance with FGFR3 mutation analysis on urine to partially replace cystoscopy may be cost-effective (J Urol 2013;189:1676)
  • Help diagnose upper urinary tract urothelial carcinoma (BMC Urol 2012;12:20)
  • Help diagnose (with ultrasound) FGFR3-related skeletal dysplasias in utero
Diagrams / tables

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FGFR3 and downstream pathways

t(4;14) in myeloma

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Missing Image

Mutations in inverted
urothelial papilloma

Microscopic (histologic) images

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Fetal growth plate: (a) osteophytes, (b) chondrocytes

Bladder: urothelial carcinoma

Pancreas: strong cytoplasmic staining of
islets, but not glandular epithelium or
ducts (Fig 7A)

Salivary gland (Fig 8A)

Skin: malignant acanthosis nigricans
(a) Internal root sheath of normal hair follicle (positive control)
(b) Axillary skin in malignant acanthosis nigricans
(c) Verrucous plaque

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Prostate: top-BPH, bottom-adenocarcinoma

Skin: seborrheic keratoses (figure d)

Positive staining - normal
  • Pancreatic islets (not acini, not ducts)
  • Salivary gland-sublingual (ducts, not epithelial cells)
  • Skin: normal hair follicle
Positive staining - disease
  • Prostate: nodular hyperplasia, adenocarcinoma
  • Skin: malignant acanthosis nigricans, seborrheic keratoses
  • Urothelial carcinoma (low grade, occasionally high grade), urothelial papilloma (classic, inverted)