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Table of Contents
Definition / general | Uses by pathologists | Diagrams / tables | Microscopic (histologic) imagesCite this page: FLT3. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsflt3.html. Accessed July 12th, 2017.
Definition / general
- Also known as FMS-like tyrosine kinase 3, CD135
- Class III receptor tyrosine kinase that regulates hematopoiesis (US National Library of Medicine)
- Constitutive activation occurs by internal tandem duplication (ITD) (Arch Pathol Lab Med 2012;136:84); detection fast and inexpensive
- Most frequent molecular abnormality in AML
- Mutated in 10% with chronic myeloproliferative diseases (CMPD) or CMPD/myelodysplastic syndrome, but not CML (Am J Clin Pathol 2006;126:530)
- Mutated in 2% with myelodysplastic syndrome (Am J Clin Pathol 2011;135:62)
- Immunophenotypic profile of TdT+ CD7+ CD13+ CD34+ CD117 (bright) predicts FLT3 mutations (100% sensitive, 94% specific, gAm J Clin Pathol 2012;137:213)
- Activated FLT3 inhibited by Sunitinib malate
Uses by pathologists
- Subtype of AML (see AML with FLT3 mutations); associated with poor clinical outcome; FLT3 mutations in AML may be unstable (Mod Pathol 2012;25:1405)
Diagrams / tables
Images hosted on other servers:
Structure and function
Images hosted on Nature.com:
Structure and function
Microscopic (histologic) images
Acute myelomonocytic leukemia: initially FLT3 mutation negative (figure A),
but FLT3+ mutation at relapse (figure B)
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