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Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 26 February 2012, last major update February 2012
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.


● Forkhead box A1 gene; also known as HNF3α (hepatocyte nuclear factor 3α)
● DNA binding protein that acts as transcriptional activator for liver specific transcripts such as albumin and transthyretin; also interacts with chromatin
● Marker of luminal A type breast cancer

Uses by pathologists

● Expression associated with good prognosis in breast cancer (Ann Surg Oncol 2011 Oct 8 [Epub ahead of print]), parallels low Oncotype DX 21-gene recurrence scores (Mod Pathol 2010;23:270)

Micro images

FOXA1 and GATA3 in breast cancer cases

End of Stains > FOXA1

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