Stains
Galectin3

Author: Nat Pernick, M.D. (see Authors page)

Revised: 2 December 2016, last major update October 2013

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Galectin-3[title]
Cite this page: Galectin3. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsgalectin3.html. Accessed December 8th, 2016.
Definition / General
  • Member of carbohydrate-binding protein family known as lectins
  • One of 14 galectins, which function as cell receptors for N-acetyl-lactosamine moieties present on most extracellular matrix components
  • Also member of the beta-galactoside-binding protein family that plays an important role in cell - cell adhesion, cell - matrix interactions, macrophage activation, angiogenesis, metastasis, apoptosis
Uses by Pathologists
  • In one study, Gal-3+ with Ki67 > 6% was associated with parathyroid carcinomas vs. adenomas (Hum Pathol 2005;36:908)
Positive Staining - Normal
  • Endothelial cells, peripheral nerve, folliculostellate cells of adenohypophysis
Positive Staining - Disease
  • Tumors of thyroid, head and neck, liver, colon, prolactinomas; parathyroid carcinoma; rarely in reactive of hyperplastic parathyroid lesions
Micro Images
Images hosted on PathOut server:

Courtesy of Andrey Bychkov, M.D., Ph.D.

Immunostaining shows intrathyroidal cancer spread

Cytoplasmic and nuclear staining



Images hosted on other servers:

Missing Image

Galectin3 in lung squamous and adenocarcinoma

Additional References