Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 December 2015, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Galectin-3[title]
Cite this page: Galectin3. website. Accessed October 25th, 2016.
Definition / General
  • Member of carbohydrate-binding protein family known as lectins
  • One of 14 galectins, which function as cell receptors for N-acetyl-lactosamine moieties present on most extracellular matrix components
  • Also member of the beta-galactoside-binding protein family that plays an important role in cell-cell adhesion, cell-matrix interactions, macrophage activation, angiogenesis, metastasis, apoptosis
Uses by Pathologists
  • In one study, Gal-3+ with Ki-67 > 6% was associated with parathyroid carcinomas vs. adenomas (Hum Pathol 2005;36:908)
Positive Staining - Normal
  • Endothelial cells, peripheral nerve, folliculostellate cells of adenohypophysis
Positive Staining - Disease
  • Tumors of thyroid, head and neck, liver, colon, prolactinomas; parathyroid carcinoma; rarely in reactive of hyperplastic parathyroid lesions
Micro Images
Missing Image

Galectin3 in lung squamous and adenocarcinoma

Additional References