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Stains

GATA3

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 5 January 2012, last major update January 2012
Copyright: (c) 2012, PathologyOutlines.com, Inc.

General
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● One of 6 members of GATA family of transcription factors
● Luminal marker for breast epithelium; also master regulator of helper T cells type 2

Terminology
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● Also known as endothelial transcription factor 3

Clinical features
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● GATA3 mutations cause HDR (hypoparathyroidism, sensorineural deafness, and renal dysplasia) syndrome (Endocr J 2011;58:117)

Uses by pathologists
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● Low GATA3 immunoexpression may be poor prognostic factor for invasive breast cancer (Hum Pathol 2010;41:1794)

Micro images
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Breast tissue (various)


Breast cancer (invasive ductal), figure c


Peripheral T cell lymphoma, NOS (fig G)

Positive staining - normal
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● Breast epithelium, T cells (mature)

Positive staining - disease
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● Breast cancer, invasive (72%, Mod Pathol 2010;23:654), well differentiated > poorly differentiated
● Peripheral T cell lymphoma NOS (30%, Am J Clin Pathol 2010;133:281)
● Urothelial carcinoma (67%, Am J Surg Pathol 2007;31:673)

Negative staining
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● Breast myoepithelial cells

End of Stains > GATA3

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