Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 June 2016, last major update January 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: GATA3
Cite this page: GATA3. website. Accessed February 21st, 2018.
Definition / general
  • One of 6 members of GATA family of transcription factors
  • Luminal marker for breast epithelium; also master regulator of helper T cells type 2
Clinical features
  • GATA3 mutations cause HDR (hypoparathyroidism, sensorineural deafness, and renal dysplasia) syndrome (Endocr J 2011;58:117)
Uses by pathologists
  • Low nuclear GATA3 immunoexpression may be poor prognostic factor for invasive breast cancer (Hum Pathol 2010;41:1794)
Microscopic (histologic) images

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Breast tissue (various)

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Breast cancer (invasive ductal), figure C

Positive staining - normal
  • A nuclear stain
  • Breast epithelium, T cells (mature)
Positive staining - disease
Negative staining
  • Breast myoepithelial cells