Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 December 2015, last major update January 2012

Copyright: (c) 2003-2015,, Inc.

PubMed Search: GATA3
Definition / General
  • One of 6 members of GATA family of transcription factors
  • Luminal marker for breast epithelium; also master regulator of helper T cells type 2
Clinical Features
  • GATA3 mutations cause HDR (hypoparathyroidism, sensorineural deafness, and renal dysplasia) syndrome (Endocr J 2011;58:117)
Uses by Pathologists
Micro Images

Images hosted on other servers:

Breast tissue (various)

Images hosted on
Missing Image

Breast cancer (invasive ductal), figure C

Positive Staining - Normal
  • Breast epithelium, T cells (mature)
Positive Staining - Disease
Negative Staining
  • Breast myoepithelial cells