Stains
GATA3

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 June 2016, last major update January 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: GATA3
Cite this page: GATA3. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsgata3.html. Accessed June 27th, 2017.
Definition / general
  • One of 6 members of GATA family of transcription factors
  • Luminal marker for breast epithelium; also master regulator of helper T cells type 2
Clinical features
  • GATA3 mutations cause HDR (hypoparathyroidism, sensorineural deafness, and renal dysplasia) syndrome (Endocr J 2011;58:117)
Uses by pathologists
  • Low nuclear GATA3 immunoexpression may be poor prognostic factor for invasive breast cancer (Hum Pathol 2010;41:1794)
Microscopic (histologic) images

Images hosted on other servers:

Breast tissue (various)



Images hosted on Nature.com:
Missing Image

Breast cancer (invasive ductal), figure C

Positive staining - normal
  • A nuclear stain
  • Breast epithelium, T cells (mature)
Positive staining - disease
Negative staining
  • Breast myoepithelial cells