Stains - Gross cystic disease fluid protein 15 (GCDFP-15)

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Stains

Gross cystic disease fluid protein 15 (GCDFP-15)

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 20 July 2012, last major update April 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

Definition
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● Also called BRST2, prolactin-induced protein (PIP)
● Glycoprotein originally isolated in human breast gross cystic fluid

Uses by pathologists
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● Differentiate breast carcinoma metastatic to ovary (positive) from primary ovarian carcinoma (negative)
● Marker of apocrine differentiation, including apocrine carcinoma of breast, although B72.3 may be more sensitive and specific (APMIS 2006;114:712)
● Less sensitive but more specific than mammaglobin in breast carcinoma in tissue (Am J Clin Pathol 2007;127:103) and similar findings in fluids (Diagn Cytopathol 2009;37:475), but mammaglobin more specific in metastatic breast carcinoma to lung and pleura (Arch Pathol Lab Med 2008;132:239)
● Differentiating primary vulvar Paget’s disease (positive) from vulvar Paget’s disease secondary to carcinoma (negative, Arch Pathol Lab Med 1998;122:1077)

Micro images
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Breast (benign)

Invasive apocrine carcinoma of the breast

Neuroendocrine carcinoma of breast

Metastatic lobular carcinoma in an endometrial polyp

Breast carcinoma metastatic to lung; to stomach (fig 3c)

Positive staining - normal
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● All apocrine, lacrimal, ceruminous and Moll's glands
● All cutaneous eccrine glands
● Numerous serous cells of submandibular, sublingual and minor salivary glands
● Also serous cells of nasal and bronchial glands (Virchows Arch 1998;432:255)

Positive staining - disease
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● Breast: lobular carcinoma (90%), primary breast carcinoma (72%), metastatic breast carcinoma (80%)
● Salivary gland carcinoma (Mod Pathol 1998;11:1033)
● Lung adenocarcinoma with apocrine features (Am J Surg Pathol 2008;32:426)
● Papillary hidradenoma (Arch Pathol Lab Med 1991;115:1249)
● Vulva - primary Paget’s disease (see Vulva chapter of PathologyOutlines.com)
● Prostate carcinoma (Hum Pathol 1989;20:281)

Negative staining
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● Vulvar Paget’s secondary to carcinoma (Hum Pathol 2002;33:545)
● Serous papillary adenocarcinoma of female genital tract (Hum Pathol 2008;39:666)
● Ovarian carcinoma (Am J Surg Pathol 2005;29:1482)

End of Stains > Gross cystic disease fluid protein 15 (GCDFP-15)

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