Gross cystic disease fluid protein 15 (GCDFP-15)

Author: Kara Hamilton, M.S. and Nat Pernick, M.D. (see Authors page)

Revised: 2 August 2018, last major update July 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: GCDFP-15
Cite this page: Hamilton, K., Pernick, N. Gross cystic disease fluid protein 15 (GCDFP-15). website. Accessed November 20th, 2018.
Definition / general
  • Also called BRST2, prolactin-induced protein (PIP)
  • Physiology: glycoprotein originally isolated in human breast gross cystic fluid
Uses by pathologists
Microscopic (histologic) images

Images hosted on PathOut server:

Invasive apocrine
carcinoma of breast

Metastatic lobular carcinoma
in an endometrial polyp

Images hosted on other servers:

Breast (benign)

Metastatic to lung

Metastatic to stomach (fig 3C)

Positive staining - normal
  • All apocrine, lacrimal, ceruminous and Moll glands
  • All cutaneous eccrine glands
  • Numerous serous cells of submandibular, sublingual and minor salivary glands
  • Also serous cells of nasal and bronchial glands (Virchows Arch 1998;432:255)
Positive staining - disease
Negative staining