Gross cystic disease fluid protein 15 (GCDFP-15)

Topic Completed: 1 July 2013

Revised: 12 April 2019

Revised: 18 January 2019

Copyright: (c) 2003-2019,, Inc.

PubMed Search: GCDFP-15

Nat Pernick, M.D.
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Cite this page: Hamilton K, Pernick N Gross cystic disease fluid protein 15 (GCDFP-15). website. Accessed August 22nd, 2019.
Definition / general
  • Also called BRST2, prolactin-induced protein (PIP)
  • Physiology: glycoprotein originally isolated in human breast gross cystic fluid
Uses by pathologists
Microscopic (histologic) images

Invasive apocrine
carcinoma of breast

Metastatic lobular carcinoma
in an endometrial polyp

Images hosted on other servers:

Breast (benign)

Metastatic to lung

Metastatic to stomach (fig 3C)

Positive staining - normal
  • All apocrine, lacrimal, ceruminous and Moll glands
  • All cutaneous eccrine glands
  • Numerous serous cells of submandibular, sublingual and minor salivary glands
  • Also serous cells of nasal and bronchial glands (Virchows Arch 1998;432:255)
Positive staining - disease
Negative staining
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