Gross cystic disease fluid protein 15 (GCDFP-15)

Topic Completed: 1 July 2013

Minor changes: 31 August 2020

Copyright: 2003-2020,, Inc.

PubMed Search: GCDFP-15

Nat Pernick, M.D.
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Cite this page: Pernick N. Gross cystic disease fluid protein 15 (GCDFP-15). website. Accessed September 23rd, 2020.
Definition / general
  • Also called BRST2, prolactin-induced protein (PIP)
  • Physiology: glycoprotein originally isolated in human breast gross cystic fluid
Uses by pathologists
Microscopic (histologic) images

Case #68

Invasive apocrine
carcinoma of breast

Case #125

Metastatic lobular carcinoma
in an endometrial polyp

Images hosted on other servers:

Breast (benign)

Positive staining - normal
  • All apocrine, lacrimal, ceruminous and Moll glands
  • All cutaneous eccrine glands
  • Numerous serous cells of submandibular, sublingual and minor salivary glands
  • Also serous cells of nasal and bronchial glands (Virchows Arch 1998;432:255)
Positive staining - disease
Negative staining
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