Stains & molecular markers
GLUT1


Topic Completed: 4 May 2020

Minor changes: 4 May 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: GLUT1[TI] review[PT]

Shaofeng Yan, M.D., Ph.D.
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Cite this page: Yan S. GLUT1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsglut1.html. Accessed July 7th, 2020.
Definition / general
  • Glucose transporter isoform 1, GLUT1, is a member of a family of glucose transporters, proteins that catalyze bidirectional transfer of substrates, particularly glucose, across cell membranes
  • GLUT are key rate limiting factors for glucose metabolism (Melanoma Res 2019;29:603)
Essential features
Terminology
  • Glucose transporter isoform 1, GLUT1, GLUT-1
Pathophysiology
Clinical features
  • Upregulation of GLUT1 has been identified in various neoplastic processes
Interpretation
  • Membrane staining pattern
Uses by pathologists
Prognostic factors
Microscopic (histologic) images

Contributed by Shaofeng Yan, M.D., Ph.D.

Infantile hemangioma

GLUT1, infantile hemangioma

Sclerosing perineurioma

GLUT1, sclerosing perineurioma

Positive staining - normal
Positive staining - disease
Negative staining
Board review style question #1


A 2 year old boy has a vascular lesion on the cheek. The lesional endothelial cells are positive for GLUT1 by immunohistochemistry. Which of the following diagnoses is most consistent with this lesion?

  1. Angiokeratoma
  2. Infantile hemangioma
  3. Microvenular hemangioma
  4. Vascular malformation
Board review answer #1
B. Infantile hemangioma

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Reference: GLUT1
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