Stains
Glypican 3 (GPC3)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 December 2015, last major update November 2011

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: GPC3
Cite this page: Glypican 3. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsglypican3.html. Accessed December 7th, 2016.
Definition / General
Interpretation
  • Cytoplasmic and membranous staining
Uses by Pathologists
Micro Images


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Staining in cirrhotic nodules (occurs occasionally)

Hepatocellular carcinoma

Placental site trophoblastic tumor and other uterine/cervical lesions



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Gestational endometrium

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Staining in cirrhotic nodules (occurs occasionally)

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Hepatic adenoma (negative)


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Hepatocellular carcinoma


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Figures e/f: fibrolamellar and hepatocellular carcinoma

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Figures c1/c2: CNS yolk sac tumor

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Left: ovarian yolk sac tumor; right: ovarian clear cell adenocarcinoma

Cytology Images

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Hepatocellular carcinoma

Positive Staining - Not Malignant
Positive staining - Tumors