Stains
Hales colloidal iron



Topic Completed: 1 June 2005

Revised: 5 March 2019

Copyright: 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: colloidal iron[title]
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Cite this page: Pernick N. Hales colloidal iron. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainshales.html. Accessed March 24th, 2019.
Definition / general
  • Kidney tumors: stain must have pH between 1.5 and 2.0
  • Clear cell and papillary renal carcinoma have focal, coarse, droplike staining
  • Note: hemosiderin in any tumors will also stain positive
Uses by pathologists
  • Helpful in distinguishing chromophobe renal cell carcinoma (intensely positive in large percentage of cells with reticular staining) from oncocytoma (usually negative; if positive - fewer cells with less intensity and dustlike staining)
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