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Hep Par1 antibody

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 15 April 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.


Hepatocyte Paraffin 1; also called Hep Par1, Hep
● Recognizes mitochondrial antigen of hepatocytes
● Highly sensitive (92%); negative in higher nuclear grade tumors (Am J Surg Pathol 2002;26:978)
● Moderately specific; false positive cases were CK7+ or CK20+ (adenocarcinoma), chromogranin+ or synaptophysin+ (neuroendocrine)
● May be biomarker for early Barrett esophagus (Am J Clin Pathol 2012;137:111)
Interpretation: granular cytoplasmic staining due to mitochondrial binding (Am J Clin Pathol 2006;125:722)

Uses by pathologists

● Determine hepatocellular origin, particularly in panel with alpha-fetoprotein and CEA or CD10 (canalicular pattern, more specific than Hep Par1)
● Differentiate hepatocellular carcinoma from cholangiocarcinoma or metastases to liver, as part of panel (Malays J Pathol 2006;28:87)

Micro images

Colon: tubular adenoma with low grade dysplasia shows focal granular cytoplasmic staining

Colon: tubular adenoma with high grade dysplasia shows strong staining

Colon: adenocarcinoma shows strong staining

Liver: normal

Liver: hepatocellular carcinoma-fibrolamellar variant

Liver: highly malignant adult hepatic blastoma (fig C)

Small intestine: normal

Small intestine: adenocarcinoma

Various images

Positive staining - normal

● Hepatocytes, small intestinal epithelium

Positive staining - disease

● Most hepatocellular carcinomas and its metastases (Int J Surg Pathol 2010;18:433), some colon adenocarcinomas and some nonhepatocellular carcinomas metastatic to liver

Negative staining

● Bile duct adenoma, hepatoid adenocarcinoma (often)

End of Stains > Hep Par1 antibody

Ref Updated: 4/2/12

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