Stains & CD markers
HepPar1
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Hep Par1 antibody
HepPar1
Author: Nat Pernick, M.D.
Last author update: 1 April 2012
Last staff update: 18 June 2021
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Hep Par1 antibody
Table of Contents
Definition / general | Interpretation | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. HepPar1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsheppar1.html. Accessed April 20th, 2024.
Definition / general
- Hepatocyte Paraffin 1
- Also called Hep Par1, Hep
- Recognizes mitochondrial antigen of hepatocytes
- Highly sensitive (92%); negative in higher nuclear grade tumors (Am J Surg Pathol 2002;26:978)
- Moderately specific; false positive cases were CK7+ or CK20+ (adenocarcinoma), chromogranin+ or synaptophysin+ (neuroendocrine)
- May be biomarker for early Barrett esophagus (Am J Clin Pathol 2012;137:111)
Interpretation
- Granular cytoplasmic staining due to mitochondrial binding (Am J Clin Pathol 2006;125:722)
Uses by pathologists
- Determine hepatocellular origin, particularly in panel with alpha-fetoprotein and CEA or CD10 (canalicular pattern, more specific than Hep Par1)
- Differentiate hepatocellular carcinoma from cholangiocarcinoma or metastases to liver, as part of panel (Malays J Pathol 2006;28:87)
Microscopic (histologic) images
Case #161
Liver, hepatocellular carcinoma, fibrolamellar
Images hosted on other servers:
Colon, tubular adenoma, low grade dysplasia, focal granular cytoplasmic staining
Colon, tubular adenoma, high grade dysplasia
Colon, adenocarcinoma, strong staining
Positive staining - normal
- Hepatocytes, small intestinal epithelium
Positive staining - disease
- Most hepatocellular carcinomas and its metastases (Int J Surg Pathol 2010;18:433), some colon adenocarcinomas and some nonhepatocellular carcinomas metastatic to liver
Negative staining
- Bile duct adenoma, hepatoid adenocarcinoma (often)
