Stains
Hep Par1 antibody



Topic Completed: 1 April 2012

Revised: 6 March 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Hep Par1 antibody
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Cite this page: Pernick N. Hep Par1 antibody. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsheppar1.html. Accessed April 19th, 2019.
Definition / general
  • Hepatocyte Paraffin 1
    • Also called Hep Par1, Hep
  • Recognizes mitochondrial antigen of hepatocytes
  • Highly sensitive (92%); negative in higher nuclear grade tumors (Am J Surg Pathol 2002;26:978)
  • Moderately specific; false positive cases were CK7+ or CK20+ (adenocarcinoma), chromogranin+ or synaptophysin+ (neuroendocrine)
  • May be biomarker for early Barrett esophagus (Am J Clin Pathol 2012;137:111)
Interpretation
Uses by pathologists
  • Determine hepatocellular origin, particularly in panel with alpha-fetoprotein and CEA or CD10 (canalicular pattern, more specific than Hep Par1)
  • Differentiate hepatocellular carcinoma from cholangiocarcinoma or metastases to liver, as part of panel (Malays J Pathol 2006;28:87)
Microscopic (histologic) images

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Liver, hepatocellular carcinoma, fibrolamellar



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Colon, tubular adenoma, low grade dysplasia, focal granular cytoplasmic staining

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Colon, tubular adenoma, high grade dysplasia

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Colon, adenocarcinoma, strong staining

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Liver, adult hepatic blastoma, Fig C

Positive staining - normal
  • Hepatocytes, small intestinal epithelium
Positive staining - disease
  • Most hepatocellular carcinomas and its metastases (Int J Surg Pathol 2010;18:433), some colon adenocarcinomas and some nonhepatocellular carcinomas metastatic to liver
Negative staining
  • Bile duct adenoma, hepatoid adenocarcinoma (often)
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