Stains
Hep Par1 antibody

Author: Nat Pernick, M.D. (see Authors page)

Revised: 1 December 2015, last major update April 2012

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: Hep Par1 antibody

Cite this page: Hep Par1 antibody. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsheppar1.html. Accessed December 2nd, 2016.
Definition / General
  • Hepatocyte Paraffin 1
    • Also called Hep Par1, Hep
  • Recognizes mitochondrial antigen of hepatocytes
  • Highly sensitive (92%); negative in higher nuclear grade tumors (Am J Surg Pathol 2002;26:978)
  • Moderately specific; false positive cases were CK7+ or CK20+ (adenocarcinoma), chromogranin+ or synaptophysin+ (neuroendocrine)
  • May be biomarker for early Barrett esophagus (Am J Clin Pathol 2012;137:111)
Interpretation
Uses by Pathologists
  • Determine hepatocellular origin, particularly in panel with alpha-fetoprotein and CEA or CD10 (canalicular pattern, more specific than Hep Par1)
  • Differentiate hepatocellular carcinoma from cholangiocarcinoma or metastases to liver, as part of panel (Malays J Pathol 2006;28:87)
Micro Images

Images hosted on PathOut server:

Missing Image

Liver, hepatocellular carc, fibrolamellar variant



Images hosted on Other servers:

Missing Image Missing Image

Colon, tubular adenoma, low grade dysplasia, focal granular cytoplasmic staining

Missing Image

Colon, tubular adenoma, high grade dysplasia

Missing Image Missing Image

Colon, adenocarcinoma, strong staining

Missing Image

Liver, normal

Missing Image

Liver, adult hepatic blastoma, Fig.C

Missing Image

Small intestine, normal

Missing Image

Small intestine, adenocarcinoma



Nature images:

Missing Image Missing Image

Various images

Positive Staining - Normal
  • Hepatocytes, small intestinal epithelium
Positive Staining - Disease
  • Most hepatocellular carcinomas and its metastases (Int J Surg Pathol 2010;18:433), some colon adenocarcinomas and some nonhepatocellular carcinomas metastatic to liver
Negative Staining
  • Bile duct adenoma, hepatoid adenocarcinoma (often)