Stains
HepPar1


Topic Completed: 1 April 2012

Revised: 6 May 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Hep Par1 antibody

Nat Pernick, M.D.
Page views in 2018: 6,684
Page views in 2019 to date: 8,137
Cite this page: Pernick N. HepPar1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsheppar1.html. Accessed December 12th, 2019.
Definition / general
  • Hepatocyte Paraffin 1
    • Also called Hep Par1, Hep
  • Recognizes mitochondrial antigen of hepatocytes
  • Highly sensitive (92%); negative in higher nuclear grade tumors (Am J Surg Pathol 2002;26:978)
  • Moderately specific; false positive cases were CK7+ or CK20+ (adenocarcinoma), chromogranin+ or synaptophysin+ (neuroendocrine)
  • May be biomarker for early Barrett esophagus (Am J Clin Pathol 2012;137:111)
Interpretation
Uses by pathologists
  • Determine hepatocellular origin, particularly in panel with alpha-fetoprotein and CEA or CD10 (canalicular pattern, more specific than Hep Par1)
  • Differentiate hepatocellular carcinoma from cholangiocarcinoma or metastases to liver, as part of panel (Malays J Pathol 2006;28:87)
Microscopic (histologic) images

Images hosted on PathOut server:
Missing Image

Liver, hepatocellular carcinoma, fibrolamellar



Images hosted on other servers:
Missing Image Missing Image

Colon, tubular adenoma, low grade dysplasia, focal granular cytoplasmic staining

Missing Image

Colon, tubular adenoma, high grade dysplasia

Missing Image Missing Image

Colon, adenocarcinoma, strong staining

Missing Image

Liver, adult hepatic blastoma, Fig C

Positive staining - normal
  • Hepatocytes, small intestinal epithelium
Positive staining - disease
  • Most hepatocellular carcinomas and its metastases (Int J Surg Pathol 2010;18:433), some colon adenocarcinomas and some nonhepatocellular carcinomas metastatic to liver
Negative staining
  • Bile duct adenoma, hepatoid adenocarcinoma (often)
Back to top