Stains
HER2 nonbreast


Topic Completed: 1 December 2012

Revised: 6 May 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: HER2 [title]
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Cite this page: Pernick N HER2 nonbreast. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsher2.html. Accessed May 24th, 2019.
Definition / general
  • Also called Human Epidermal growth factor Receptor 2, c-erbB2, neu, ERBB2 and CD340
  • HER2 gene encodes transmembrane glycoprotein (p185) with tyrosine kinase activity
  • Related to EGFR
  • May cross reactive with P glycoprotein / CD243
  • Receptor acts via homo or heterodimerization with other EGFR family receptors
  • In embryogenesis, helps establish several cell lineages through mesenchyme-epithelial-neuroectodermal inductive processes
  • Influences cellular migration, differentiation, and interactions between cells
Interpretation
Uses by pathologists
  • Gastric and gastroesophageal junction adenocarcinoma: determine use of anti-HER2 therapies (Arch Pathol Lab Med 2012;136:691), which improve survival in HER2+ patients
Microscopic (histologic) images

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Bladder,
carcinoma in situ,
full thickness
HER2+ staining

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HER2 oncoprotein


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Esophagus, adenocarcinoma

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Stomach, gastric and gastroesophageal junction adenocarcinoma



Positive staining - disease
Negative staining
  • Skin: Bowen disease
Molecular / cytogenetics images

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Esophagus, adenocarcinoma

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