Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 November 2015, last major update May 2013

Copyright: (c) 2002-2015,, Inc.

Cite this page: HHV8 / KSHV. website. Accessed October 17th, 2018.
Definition / general
  • Human Herpes Virus 8; also known as Kaposi’s Sarcoma-associated Herpes Virus
  • Gamma herpesvirus identified as an etiologic agent for Kaposi’s sarcoma in 1994
  • Latently infects endothelial cells, monocytes and B cells in Kaposi’s sarcoma patients
  • Associated with 3 HIV associated lymphoproliferative disorders - primary effusion lymphoma, multicentric Castleman’s disease and multicentric Castleman’s disease-associated plasmablastic lymphoma
  • Sensitive but not specific for Kaposi’s sarcoma, due to presence in other tumors (including hemangiomas) in immunocompromised (may be present within intratumoral blood mononuclear cells, Mod Pathol 2005;18:463)
  • References: Am J Surg Pathol 2002;26:1363
Microscopic (histologic) images

Images hosted on Flickr:

Soft tissue, foot: Kaposi's sarcoma