Topic Completed: 1 June 2005

Minor changes: 6 March 2019

Copyright: 2003-2015,, Inc.

PubMed Search: HLA-G[title]

Nat Pernick, M.D.
Page views in 2019: 203
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Cite this page: Pernick N. HLA-G. website. Accessed July 4th, 2020.
Definition / general
  • Non-classical MHC class I antigen that interacts with NK cells, can present nonamer peptides and binds CD8 analogous to classic HLA class 1 proteins
  • May play a role in maternal tolerance toward fetal tissue
  • Sensitive and specific for intermediate trophoblast in all types of gestational trophoblastic tissue (including tumors) in initial study (Am J Surg Pathol 2002;26:914)
  • Focal staining in melanoma, renal cell carcinoma, large cell carcinoma of the lung
Negative staining
  • Cytotrophoblast, syncytiotrophoblast
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