Stains
HLA-G

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 November 2015, last major update June 2005

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: HLA-G[title]

Definition / General
  • Non-classical MHC class I antigen that interacts with NK cells, can present nonamer peptides and binds CD8 analogous to classic HLA class 1 proteins
  • May play a role in maternal tolerance toward fetal tissue
  • Sensitive and specific for intermediate trophoblast in all types of gestational trophoblastic tissue (including tumors) in initial study (Am J Surg Pathol 2002;26:914)
  • Focal staining in melanoma, renal cell carcinoma, large cell carcinoma of the lung
Negative Staining
  • Cytotrophoblast, syncytiotrophoblast