Stains
HLA-G



Topic Completed: 1 June 2005

Revised: 6 March 2019

Copyright: 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: HLA-G[title]
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Cite this page: Pernick N. HLA-G. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainshlag.html. Accessed May 24th, 2019.
Definition / general
  • Non-classical MHC class I antigen that interacts with NK cells, can present nonamer peptides and binds CD8 analogous to classic HLA class 1 proteins
  • May play a role in maternal tolerance toward fetal tissue
  • Sensitive and specific for intermediate trophoblast in all types of gestational trophoblastic tissue (including tumors) in initial study (Am J Surg Pathol 2002;26:914)
  • Focal staining in melanoma, renal cell carcinoma, large cell carcinoma of the lung
Negative staining
  • Cytotrophoblast, syncytiotrophoblast
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