Topic Completed: 1 June 2005

Minor changes: 6 March 2019

Copyright: 2003-2015,, Inc.

PubMed Search: Interleukin 1 beta Converting Enzyme[title]

Nat Pernick, M.D.
Page views in 2019: 26
Page views in 2020 to date: 9
Table of Contents
Definition / general
Cite this page: Pernick N. ICE. website. Accessed June 4th, 2020.
Definition / general
  • Interleukin 1 beta Converting Enzyme; related to ced-3 in C. elegans
  • Formed from cleavage of pro-ICE; then activates inflammatory cytokine interleukin 1 beta
  • Has early role is signaling pathway for Fas dependent apoptosis
  • Nuclear substrates: PARP, U1 RNP (U1-70 kDa), nuclear lamins, DNA dependent protein kinase
  • Cytoplasmic substrates: protein kinase C delta, actin / other parts of cytoskeleton
  • Inhibitors: p35 (baculovirus protein), CrmA (poxviral protein), aldehydes; no cellular counterparts known
Back to top