Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 November 2015, last major update June 2005

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PubMed Search: Interleukin 1 beta Converting Enzyme[title]

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Table of Contents
Definition / general
Cite this page: ICE. website. Accessed January 18th, 2019.
Definition / general
  • Interleukin 1 beta Converting Enzyme; related to ced-3 in C. elegans
  • Formed from cleavage of pro-ICE; then activates inflammatory cytokine interleukin 1 beta
  • Has early role is signaling pathway for Fas dependent apoptosis
  • Nuclear substrates: PARP, U1 RNP (U1-70 kDa), nuclear lamins, DNA dependent protein kinase
  • Cytoplasmic substrates: protein kinase C delta, actin / other parts of cytoskeleton
  • Inhibitors: p35 (baculovirus protein), CrmA (poxviral protein), aldehydes; no cellular counterparts known