Topic Completed: 1 November 2013

Revised: 6 March 2019

Copyright: 2015-2018,, Inc.

PubMed Search: IDH1 stain

Nat Pernick, M.D.
Page views in 2018: 4,831
Page views in 2019 to date: 3,735
Cite this page: Pernick N. IDH1. website. Accessed September 16th, 2019.
Definition / general
Diagrams / tables

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Role in TCA cycle

Catalyzation of wild-type and mutant IDH1 and IDH2 reactions

Uses by pathologists
  • Bone: IDH1/2 mutation may differentiate chondrosarcoma (mutation present) from chondroblastic osteosarcoma (mutation not present, Am J Surg Pathol 2013;37:787); presence of IDH1/2 mutations may confirm diagnosis of dedifferentiated chondrosarcoma if osteosarcomatous differentiation present
  • CNS - glioma and glioblastoma:
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by GenomeMe

Astrocytoma, IDH1-R132H, clone IHC132

Glioma. IDH1-R132H, clone IHC132

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Kidney: normal

Oligoastrocytoma, anaplastic


Positive staining - disease
Negative staining
  • Primary glioblastoma (includes small cell, granular cell, giant cell variants)
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