Stains
IDH1

Author: Nat Pernick, M.D.

Revised: 3 August 2018, last major update November 2013

Copyright: (c) 2015-2018, PathologyOutlines.com, Inc.

PubMed Search: IDH1 stain

Cite this page: Pernick, N. IDH1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsidh1.html. Accessed August 14th, 2018.
Definition / general
Diagrams / tables

Images hosted on other servers:

Role in TCA cycle

Catalyzation of wild-type and mutant IDH1 and IDH2 reactions

Uses by pathologists
  • Bone: IDH1/2 mutation may differentiate chondrosarcoma (mutation present) from chondroblastic osteosarcoma (mutation not present, Am J Surg Pathol 2013;37:787); presence of IDH1/2 mutations may confirm diagnosis of dedifferentiated chondrosarcoma if osteosarcomatous differentiation present
  • CNS - glioma and glioblastoma:
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by GenomeMe

Astrocytoma, IDH1-R132H, clone IHC132

Glioma. IDH1-R132H, clone IHC132



Images hosted on other servers:

Kidney: normal

Oligoastrocytoma, anaplastic

Glioblastoma


Positive staining - disease
Negative staining
  • Primary glioblastoma (includes small cell, granular cell, giant cell variants)