Stains
IgH

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 December 2015, last major update May 2012

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PubMed Search: IgH [title]

Definition / General
Interpretation
  • Fusion genes involving IgH (common, 10% or more):
    • BCL1-IgH [due to t(11;14)(q13;q32)]: mantle cell lymphoma (90%), B cell prolymphocytic leukemia (20%), splenic lymphoma with villous lymphocytes (10%), CLL (2 - 5%), myeloma (2 - 5%)
      • BCL1 is also known as cyclin D1
    • BCL2-IgH [due to t(14;18)]: follicular lymphoma (80%+), diffuse large cell lymphoma (30%), CLL (occasional)
    • BCL2-IgH and MYC-IGH: "double-hit" lymphoma (Am J Surg Pathol 2010;34:327)
    • BCL3-IgH [due to t(14;19)(q32;q13)]: CLL / SLL (4 - 20%, Am J Clin Pathol 2011;135:686)
    • BCL6-IgH [due to t(3;14)(q27;q32)]: diffuse large B cell lymphoma (30%), follicular lymphoma (10%), nodular lymphocyte predominant Hodgkin lymphoma (some, J Mol Diagn 2005;7:352)
    • FGFR3-IgH [due to t(4;14)(p16;q32)]: myeloma (20-30%)
    • MALT1-IgH [due to t(14;18)(q32;q21)]: MALT lymphoma (11%, but varies by site, Leukemia 2004;18:1722)
    • MUM / IRF4-IgH [due to t(6;14)(p25;q32)]: myeloma (20%)
    • MYC-IgH [due to t(8;14)(q24;q32.3)]: Burkitt lymphoma (75%), plasmablastic lymphoma (~35%, Am J Surg Pathol 2010;34:1686, Am J Clin Pathol 2009;132:597), ALL-L3 (6%)
    • PAX5-IgH [due to t(9;14)(p13;q32)]: lymphoplasmacytic lymphoma (0 - 50%), diffuse large B cell lymphoma and other B cell lymphoproliferative disorders

  • Fusion genes involving IgH (uncommon, <10%):
Molecular / Cytogenetics Images

Images hosted on Other servers:
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IGH-BCL1, mantle cell lymphoma

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IGH-BCL2, "double-hit" lymphoma

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GH-BCL6 juxtaposition

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IGH-MALT1 in MALT