Immunohistochemistry - common panels

Author: Nat Pernick, M.D. (see Authors page)

Revised: 28 August 2015, last major update August 2015

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Immunohistochemistry common panels
Table of Contents
  • Epithelial markers: low molecular weight keratin (CAM 5.2), AE1-AE3 cytokeratin cocktail, CK7, CK20, CEA and EMA
  • Alternative epithelial markers on sarcomatoid carcinoma include p63, MOC-31 and TTF1 (Mod Pathol 2005;18:1471)

  • Melanocytic markers: S100 (also a mesenchymal marker), HMB45, MelanA / Mart1

  • Lymphoid markers: CD3 (T cells), CD20 (B cells), CD15 (Hodgkin), CD30 (Hodgkin & other) and various others

  • Histiocytic markers: CD68, lysozyme, CD1a (Langerhans cells)

  • Neuroendocrine markers: neuron specific enolase, chromogranin, synaptophysin, CD56 and CD57

  • Mesenchymal markers: vimentin (non-specific), factor XIIIa (fibrous histiocytoma), factor VIII (vessels), CD31 (vessels), CD34 (vessels), D2-40 (lymphatics), HHF35 (actin), smooth muscle actin and desmin

  • Cell proliferation / apoptosis markers: Ki-67, bcl2