Topic Completed: 1 March 2016

Revised: 6 March 2019

Copyright: (c) 2002-2016,, Inc.

PubMed Search: ING2[title]

Related topics: ING1, ING3

Page views in 2018: 6
Page views in 2019 to date: 8
Cite this page: Enwere E, Thakur S. ING2. website. Accessed September 18th, 2019.
Definition / general
  • The ING family (ING1-5) of tumor suppressors are involved in a broad range of cellular processes
  • The tumor suppressive properties of INGs are due to their ability to induce apoptosis, senescence and inhibition of cell migration
  • Due to their ability to interact with histones, all ING proteins are categorized as "histone readers" and can regulate gene expression epigenetically
  • ING2 functionally interacts with the tumor suppressor protein p53 to regulate cellular senescence, apoptosis and DNA damage response in vitro; it thus modulates carcinogenesis and aging
  • Like ING1, ING2 negatively regulates cell growth in a p53 dependent manner; DNA damaging agents such as etoposide induce ING2 expression (Cell 2003;114:99)
Clinical features
Uses by pathologists
  • Targeted germline disruption of ING2 in male mice leads to abnormal spermatogenesis and infertility
  • Testes of ING2 knockout mice show degeneration of seminiferous tubules, meiotic arrest, induction of p53 and enhanced apoptosis
  • ING2 knockout mice also show increased incidence of soft tissue sarcoma (PLoS One 2010;5:e15541)
Microscopic (histologic) images

Representative images of ING2 immunohistochemical staining in human melanocytic lesions

Positive staining - normal
  • Cervix, Ovary, Placenta, Testis
Positive staining - disease
  • Head and Neck Cancer, Lung cancer, Ovarian Cancer, Pancreatic Cancer, Thyroid Cancer
Negative staining
  • Most tissues show moderate to weak nuclear ING1-2 staining
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