Inhibin A

Author: Nat Pernick, M.D. (see Authors page)

Revised: 20 November 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Inhibin A[title]

Definition / General
  • Inhibin is a heterodimeric protein (with alpha and beta subunits) that inhibits or activates pituitary FSH secretion
  • Serum levels elevated (2x) in women with Down's fetus
Positive Staining - Normal
  • Sertoli cells (diffuse and strong), granulosa cells, prostate, brain, adrenal
Positive Staining - Disease
  • Sex-cord stromal tumors, including Sertoli cell tumors, adrenocortical tumors, placental and gestational trophoblastic lesions, granular cell tumors of gallbladder and extrahepatic bile ducts (Am J Surg Pathol 2001;25:1200), some carcinomas
Negative Staining
  • Primary ovarian carcinomas (usually)
Micro Images

Adrenocortical oncocytic carcinoma