Author: Nat Pernick, M.D. (see Authors page)

Revised: 24 November 2015, last major update November 2013

Copyright: (c) 2015,, Inc.

PubMed Search: ISL1

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PubMed Search: ISL1[title]

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Cite this page: ISL1. website. Accessed January 22nd, 2019.
Definition / general
  • Insulin gene enhancer-binding protein islet-1 (ISL1); also called ISLET1, LIM homeodomain gene Islet-1 (GeneCards)
Microscopic (histologic) images

Heart between 26 and 38 days of gestation

Positive staining - normal
Positive staining - disease
  • Pancreatic (well differentiated) and other neuroendocrine tumors
Negative staining
  • Poorly differentiated pancreatic endocrine tumors