Author: Nat Pernick, M.D. (see Authors page)

Revised: 24 November 2015, last major update November 2013

Copyright: (c) 2015,, Inc.

PubMed Search: ISL1

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PubMed Search: ISL1[title]

Definition / General
  • Insulin gene enhancer-binding protein islet-1 (ISL1); also called ISLET1, LIM homeodomain gene Islet-1 (GeneCards)
Micro Images

Heart between 26 and 38 days of gestation

Positive Staining - Normal
Positive Staining - Disease
  • Pancreatic (well differentiated) and other neuroendocrine tumors
Negative Staining
  • Poorly differentiated pancreatic endocrine tumors