Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 November 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: JAK[title]

Definition / General
  • Family whose members (JAK1-3, Tyk2) are critical for cytokine signaling
  • Associated with intracytoplasmic portion of cytokine receptors, which serves as docking site for STAT monomers; activated JAK activates and phosphorylates the STAT monomers, which then dissociate, dimerize and migrate to nuclear, where they interact with specific DNA binding elements and activate transcription of cyclin D1, bcl-Xl, bax, bcl2, c-myc, c-Jun, c-kit, and IL-10
  • Jak3: Janus kinase 3, a tyrosine kinase that activates STAT3 in response to cytokine stimulation
  • Positive staining (disease): ALK+ anaplastic large cell lymphoma (Hum Pathol 2005;36:939)
Additional References