Stains
JunB



Topic Completed: 1 June 2005

Revised: 6 March 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: JunB[title]
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Cite this page: Pernick N. JunB. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsjunb.html. Accessed March 24th, 2019.
Definition / general
  • At 19p13
  • Member of Jun family of proteins (also c-Jun and JunD), that are components of AP-1 transcription factor complex, involved in cell proliferation and apoptosis
  • May bind with CD30 gene promoter
Interpretation
  • Nuclear stain
Positive staining - disease
  • Anaplastic large cell lymphoma (ALK+ or negative; cutaneous or not), classic Hodgkin lymphoma, CD30+ diffuse large B cell lymphoma, lymphomatoid papulosis
Negative staining
  • Nodular lymphocyte predominant Hodgkin lymphoma, CD30- diffuse large cell lymphoma
Additional references
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