Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 27 September 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: JunB[title]
- At 19p13
- Member of Jun family of proteins (also c-Jun and JunD), that are components of AP-1 transcription factor complex, involved in cell proliferation and apoptosis
- May bind with CD30 gene promoter
Positive staining - disease
- Anaplastic large cell lymphoma (ALK+ or negative; cutaneous or not), classic Hodgkin lymphoma, CD30+ diffuse large B cell lymphoma, lymphomatoid papulosis
- Nodular lymphocyte predominant Hodgkin lymphoma, CD30- diffuse large cell lymphoma
Classic Hodgkin lymphoma and anaplastic large cell lymphoma
End of Stains > JunB
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