Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 November 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: JunB[title]

Definition / General
  • At 19p13
  • Member of Jun family of proteins (also c-Jun and JunD), that are components of AP-1 transcription factor complex, involved in cell proliferation and apoptosis
  • May bind with CD30 gene promoter
  • Nuclear stain
Positive Staining - Disease
  • Anaplastic large cell lymphoma (ALK+ or negative; cutaneous or not), classic Hodgkin lymphoma, CD30+ diffuse large B cell lymphoma, lymphomatoid papulosis
Negative Staining
  • Nodular lymphocyte predominant Hodgkin lymphoma, CD30- diffuse large cell lymphoma
Micro Images

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CD30+ lymphomas

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Classic Hodgkin lymphoma and anaplastic large cell lymphoma

Additional References