Cytokeratin KL-1

Stains
Cytokeratin KL-1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 December 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: KL-1

Table of Contents

Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - disease | Microscopic (histologic) images

Cite this page: Cytokeratin KL-1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainskl1.html. Accessed July 12th, 2017.

Definition / general

Broad spectrum keratin antibody for CK1-4, 10-11 (Jpn J Clin Oncol 1998;28:480) or CK1, 2, 5-8, 11, 14, 16-18
Not used as frequently as AE1/AE3

Uses by pathologists

Detect tumor cells in bone marrow (Jpn J Clin Oncol 1998;28:480)
Detect micrometastases in lymph nodes (Mod Pathol 2002;15:641)
Label tumor cells for flow cytometry from archival specimens (Am J Clin Pathol 1998;110:227)

Positive staining - normal

Most epithelium (J Invest Dermatol 1983;81:351)

Positive staining - disease

Most carcinomas
Craniopharyngioma (Acta Neurochir (Wien) 2001;143:147)
Liver epithelial neoplasms (Am J Pathol 1987;127:530)

Microscopic (histologic) images

Breast carcinoma metastases to axillary nodes