Author: Nat Pernick, M.D. (see Authors page)

Revised: 6 November 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Lambda[title]

Definition / General
  • Type of immunoglobulin light chain
  • Kappa/lambda ratio is usually 2:1
  • Restricted expression of either kappa or lambda suggests monoclonality and a neoplastic process
Micro Images

Images hosted on Pathout server:

Hodgkin lymphoma: neoplastic cells have
variable cytoplasmic lambda staining, plasma
cells have intense staining and histiocytes
have weak staining

Contributed by Leica Microsystems, Biosytems division:
Myeloma of bone marrow with ISH staining for
kappa (left) and lambda (right) light chains using
Kappa Probe (PB0645), Lambda Probe (PB0669)
and Bond Polymer Refine Detection