Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 August 2018, last major update June 2005

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Laminin[title]

Page views in 2018: 312
Page views in 2019 to date: 25
Cite this page: Pernick, N. Laminin. website. Accessed January 22nd, 2019.
Definition / general
  • Major component on basement membrane, with type IV collagen
  • Trimeric glycoproteins (at least 11 types) with integrin binding site
  • Defects in laminin proteins cause skin blistering and myocardial diseases
  • Antibodies to laminin inhibit lung branching morphogenesis
  • Production of alpha-1 laminin by epithelial cells and mesenchymal cells depends on extent of mesenchymal and epithelial contact with each other; modulates mesenchymal cell shape
Uses by pathologists