Stains
Laminin



Topic Completed: 1 June 2005

Revised: 6 March 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Laminin[title]
Page views in 2018: 312
Page views in 2019 to date: 93
Cite this page: Pernick N. Laminin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainslaminin.html. Accessed March 25th, 2019.
Definition / general
  • Major component on basement membrane, with type IV collagen
  • Trimeric glycoproteins (at least 11 types) with integrin binding site
  • Defects in laminin proteins cause skin blistering and myocardial diseases
  • Antibodies to laminin inhibit lung branching morphogenesis
  • Production of alpha-1 laminin by epithelial cells and mesenchymal cells depends on extent of mesenchymal and epithelial contact with each other; modulates mesenchymal cell shape
Uses by pathologists
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