Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 November 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Laminin[title]

Definition / General
  • Major component on basement membrane, with type IV collagen
  • Trimeric glycoproteins (at least 11 types) with integrin binding site
  • Defects in laminin proteins cause skin blistering and myocardial diseases
  • Antibodies to laminin inhibit lung branching morphogenesis
  • Production of alpha-1 laminin by epithelial cells and mesenchymal cells depends on extent of mesenchymal and epithelial contact with each other; modulates mesenchymal cell shape
Uses by Pathologists
Micro Images

Laminin5 expression in normal breast, DCIS and invasive ductal breast carcinoma